云南高校图书馆联盟文献共享服务平台- GRK2

GRK2: 作品数：61被引量：110H指数：5; 导出分析报告; 相关领域：医药卫生更多>>; 相关作者：魏伟高文谦严尚学屈昌雪张华更多>>; 相关机构：安徽医科大学上海交通大学中国人民解放军总医院郑州大学更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金安徽省自然科学基金国家重点基础研究发展计划国家科技支撑计划更多>>

G protein-coupled receptor kinase 2 as a novel therapeutic target for gland fibrosis of Sjögren’s syndrome: 《Acta Pharmacologica Sinica》2024年第12期2611-2624,共14页Ru-hong Fang Zheng-wei Zhou Rui Chu Qiu-yun Guan Feng He Ming-li Ge Pai-pai Guo Hua-xun Wu Ling-li Yao Wei Wei Yang Ma Qing-tong Wang; supported by the National Natural Science Foundation of China(81973314,82373865,81973332);the Anhui Provincial Natural Science Foundation for Distinguished Young Scholars(1808085J28);Collaborative Innovation Project of Key Scientific Research Platform in Anhui Universities(GXXT-2020-066);Anhui Provincial Key R&D Programs(2022e07020042);Program for Upgrading Scientific Research Level of Anhui Medical University(2019xkjT008);Academic Funding for Top-notch Talents in University Disciplines(Majors)of Anhui Province(gxbjzD2021047);Anhui Medical University 2022 Provincial New Era Education Quality Project(2022cxcysjo81);Scientific Research Foundation of Anhui Medical University(2023xkjo77)。; Sjogren’s syndrome(SS)is a chronic,progressive autoimmune disorder characterized by gland fibrosis.We previously found a close correlation between gland fibrosis and the expression of G protein-coupled receptor kinas...; 关键词：Sjögren’s syndrome SGECs GRK2 SMAD2/3 gland fibrosis PAROXETINE

美托洛尔联合重组人脑利钠肽对高龄心衰患者心功能、内皮细胞、GRK2mRNA表达的影响研究: 《中国科技期刊数据库医药》2024年第10期0096-0099,共4页王玉年; 探究美托洛尔联合重组人脑利钠肽对高龄心衰患者心功能,内皮细胞,GRK2 mRNA表达影响研究。方法选择在2020年1月至2022年1月期间在我院接受治疗的54例高龄心衰患者作为研究对象,采用奇数偶数的顺序法进行分组,分为对照组和实验组,每组...; 关键词：重组人脑利钠肽美托洛尔高龄心衰 GRK2 mRNA

CP-25通过抑制GRK2活性改善小鼠骨关节炎的机制被引量：3: 《中国药理学通报》2024年第5期936-944,共9页王惠敏王旭蕾储柱平郭婷婷徐诺王康李颖魏伟严尚学; 安徽高校自然科学研究重大项目(No KJ2020ZD15)。; 目的研究芍药苷-6-氧-苯磺酸酯(CP-25)通过抑制GRK2活性对骨关节炎(osteoarthritis,OA)小鼠膝关节软骨的保护作用。方法内侧半月板失稳(destabilization of the medial meniscus,DMM)手术诱导构建小鼠骨关节炎模型,实验分为假手术组、...; 关键词：骨关节炎软骨保护 CP-25 软骨细胞 GRK2 DMM手术

沙库巴曲缬沙坦钠对急性心肌梗死后心力衰竭患者血清sFRP5、VS-2、GRK2水平的影响: 《今日药学》2024年第5期377-381,共5页熊辉夏日辉吴高祥; 目的探讨沙库巴曲缬沙坦钠对急性心肌梗死(AMI)后心力衰竭患者血清分泌型卷曲相关蛋白5(sFRP5)、血管抑制因子-2(VS-2)、G蛋白耦联受体激酶2(GRK2)水平的影响。方法以随机数表法将江西省丰城市人民医院收治的108例AMI后心力衰竭患者分...; 关键词：沙库巴曲缬沙坦钠急性心肌梗死后心力衰竭分泌型卷曲相关蛋白5 血管抑制因子-2 G蛋白耦联受体激酶2

GRK2-YAP signaling is implicated in pulmonary arterial hypertension development: 《Chinese Medical Journal》2024年第7期846-858,共13页Peng Ye Yunfei Deng Yue Gu Pengfei Liu Jie Luo Jiangqin Pu Jingyu Chen Yu Huang Nanping Wang Yong Ji Shaoliang Chen; National Natural Scientific Foundation of China(Nos.NSFC 91639303 and NSFC 81770441); Background:Pulmonary arterial hypertension(PAH)is characterized by excessive proliferation of small pulmonary arterial vascular smooth muscle cells(PASMCs),endothelial dysfunction,and extracellular matrix remodeling.G...; 关键词：Pulmonary arterial hypertension GRK2 YAP Pulmonary artery smooth muscle cell HYPOXIA

GRK2 mediated degradation of SAV1 initiates hyperplasia of fibroblast-like synoviocytes in rheumatoid arthritis被引量：1: 《Acta Pharmaceutica Sinica B》2024年第3期1222-1240,共19页Paipai Guo Ji Jiang Rui Chu Feng He Mingli Ge Ruhong Fang Qiuyun Guan Huijuan Cheng Chunru Jiang Tiantian Su Zhenduo Zhu Hao Liu Wei Wei Shihao Zhang Qingtong Wang; supported by the National Natural Science Foundation of China(81973314,82373865,81973332,82173824);the Anhui Provincial Natural Science Foundation for Distinguished Young Scholars(1808085J28,China);Collaborative Innovation Project of Key Scientific Research Platform in Anhui Universities(GXXT-2020-066,China);the Research Program for Higher Education Institutions in Anhui Province(2022AH030081,China);Anhui Provincial Key R&D Programs(2022e07020042,China);Program for Upgrading Scientific Research Level of Anhui Medical University(2019xkj T008,China);Academic Funding for Top-notch Talents in University Disciplines(Majors)of Anhui Province(gxbj ZD2021047,China)。; Hyperplasia and migration of fibroblast-like synoviocytes(FLSs)are the key drivers in the pathogenesis of rheumatoid arthritis(RA)and joint destruction.Abundant Yes-associated protein(YAP),which is a powerful transcri...; 关键词：Rheumatoid arthritis Fibroblast-like synoviocytes G protein-coupled receptor kinase 2 Salvador homolog-1 Yes-associated protein

肝星状细胞特异性Grk2基因敲除小鼠模型的制备及鉴定被引量：1: 《中国药理学通报》2024年第1期189-194,共6页王语涵许雅萍李南陈婷婷李玲高萍萍王华魏伟孙妩弋; 国家自然科学基金资助项目(No 82370632);安徽省高校杰出青年科研项目(No 2023AH020033);安徽省转化医学研究院科研基金项目(No 2022zhyx-C07);安徽医科大学科研水平提升计划(No 2021xkjT016);安徽医科大学第三附属医院基础与临床合作研究提升计划培育专项(No 2022sfy014)。; 目的利用Cre-loxP基因敲除技术建立肝星状细胞特异性G蛋白偶联受体激酶2(G protein-coupled receptor kinase 2,GRK2)基因敲除小鼠模型,为研究GRK2在肝星状细胞中的生物学功能提供动物模型基础。方法将loxP标记的Grk2基因小鼠(Grk2^(fl/...; 关键词：G蛋白偶联受体激酶2 Cre-loxP重组酶系统细胞特异性敲除肝星状细胞基因鉴定繁育

GRK2 inhibits Flt-1^(+)macrophage infiltration and its proangiogenic properties in rheumatoid arthritis: 《Acta Pharmaceutica Sinica B》2024年第1期241-255,共15页Xuezhi Yang Yingjie Zhao Qi Wei Xuemin Zhu Luping Wang Wankang Zhang Xiaoyi Liu Jiajie Kuai Fengling Wang Wei Wei; We thank LetPub(www.letpub.com)for its linguistic assistance during the preparation of this manuscript.We thank all the patients who participated in providing us with synovial tissues and blood samples.Graphical abstract was created with BioRender.com(publication and licensing rights number JZ25ROGTF8);This study was supported by the National Natural Science Foundation of China(No.82003763,No.81973332,No.82173824,No.82204405,No.82204402);Research Fund of Anhui Institute of translational medicine(2022zhyx-B04,China);The 2022 Basic and Clinical Collaborative Research of Anhui Medical University(2022sfy015,China);Natural Science Foundation of Anhui Provincial(2108085QH383,China).; Rheumatoid arthritis(RA)is an autoimmune disease with a complex etiology.Monocyte-derived macrophages(MDMs)infiltration are associated with RA severity.We have reported the deletion of G-protein-coupled receptor kinas...; 关键词：GRK2 Monocyte-derived macrophages Rheumatoid arthritis PPARG FLT-1

猪GRK2蛋白抗口蹄疫病毒作用分析: 《畜牧兽医学报》2023年第10期4350-4361,共12页陈文哲张向乐顾峰幸赵振翔李康丽薛钊宁郑海学张小丽朱紫祥; 国家重点研发计划项目(2021YFD1800300);甘肃省重大专项(21ZD3NA001,20ZD7NA006,19ZDNA001);“十四五”广东省农业科技创新十大主攻方向“揭榜挂帅”项目(2022SDZG02);生猪产业体系(CARS-35);绒毛羊产业体系(CARS-39-13);中国农业科学院基本科研业务费(1610312022006)。; 为研究G蛋白偶联受体激酶2(G protein-coupled receptor kinase 2,GRK2)对口蹄疫病毒(foot-and-mouth disease virus,FMDV)复制的影响,从猪的PK-15细胞中提取RNA,通过聚合酶链式反应(polymerase chain reaction,PCR)扩增出猪GRK2的完整...; 关键词：口蹄疫病毒 G蛋白偶联受体激酶2 抗病毒作用

外周血SIRT1、GRK2水平对急性ST段抬高型心肌梗死病人PCI术后心力衰竭的预测价值被引量：1: 《中西医结合心脑血管病杂志》2023年第17期3234-3238,共5页张洪薛蕾王喜欢; 河南省医学科技攻关计划联合共建项目(No.LHGJ20191464)。; 目的:探讨外周血沉默信息调节因子2相关酶1(SIRT1)、G蛋白偶联受体激酶2(GRK2)水平对急性ST段抬高型心肌梗死(STEMI)病人经皮冠状动脉介入治疗(PCI)术后心力衰竭(HF)的预测价值。方法:选取195例STEMI病人,根据PCI术后6个月是否发生HF分...; 关键词：急性ST段抬高型心肌梗死经皮冠状动脉介入治疗心力衰竭沉默信息调节因子2相关酶1 G蛋白偶联受体激酶2

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