体内普罗帕酮及其代谢物的GC-MS检验  

Determination of Propafenone and Its Metabolites with GC-MS

作　　者：刘俊亭[1] 高利娜[1] 王妍[1] 

机构地区：[1]中国医科大学药学院药物分析教研室,辽宁沈阳110001

出　　处：《分析测试学报》2007年第z1期44-46,共3页Journal of Instrumental Analysis

摘　　要：In this paper,propafenone in judicial anatomy was quantitated and found to be 11.6 μg/mL in blood,17.8 μg/mL in urine,292 μg/g in gastric content and 196 μg/g in liver with GC-MS. Two metabolites from propafenone have been defined.In conclusion,as the dead body himself is a drug abuser and also his blood concentration of propafenone exceed the fatal dose,this case is finally identified to a death cause from the overdose of propanenone abuse.In this paper,propafenone in judicial anatomy was quantitated and found to be 11.6 μg/mL in blood,17.8 μg/mL in urine,292 μg/g in gastric content and 196 μg/g in liver with GC-MS. Two metabolites from propafenone have been defined.In conclusion,as the dead body himself is a drug abuser and also his blood concentration of propafenone exceed the fatal dose,this case is finally identified to a death cause from the overdose of propanenone abuse.

关 键 词：PROPAFENONE METABOLITE GC-MS 

分 类 号：O657-55[理学—分析化学]