In clinical practice, side effects of anti-arrhythmic medicines such as propafenone are commonly registered. Therapeutic drug monitoring is a solution to the problem regarding to side effects of drugs and aiming to co...
the technical platform in Shandong University and Doctor research fund of Hubei University of Art and Science(2013B009)
Objective: To determine the selective killing effect of oxytetracycline, propafenone and metamizole on A549 or Hela cells. Methods: Proliferation assay, lactate dehydrogenase (LDH) assay, apoptosis detecting, flow...
Aim: To investigate the effects of diltiazem, an L-type calcium channel blocker, and propafenone, a sodium channel blocker, on the inactivation and recovery kinetics of fKvl.4, a potassium channel that generates the ...
In this paper,propafenone in judicial anatomy was quantitated and found to be 11.6 μg/mL in blood,17.8 μg/mL in urine,292 μg/g in gastric content and 196 μg/g in liver with GC-MS. Two metabolites from propafenone ...
Objectives To observe the electrophysiologic effects of propafenone (Prop) on ischemic ventricular tachyarrhythmias. Methods A canine ischemic ventricular tachyarrhythmia model was established in open-chest dogs sub...
RAIM: To determine the effect of CYP2D6*10 genotype on propafenone pharmacodynamics in Chinese patients with ventricular arrhythmia. METHODS: Seventeen Chinese patients with ventricular premature contractions (VPC≥10...
Project supported by the National Natural Science Foundation of China(No 39770868 and No 39670801);Zhejiang Natural Science Foundation (No RC97016)
AIM: To investigate the stereoselective metabolism of propafenone ( PPF ) by human liver CYP3A4. METHODS: A chiral and an achiral HPLC were combined to determine the enantiomer of PPF in S9 incubates prepared from tra...
AIM: To study the simultaneous modeling of pharmacokinetics and pharmacodynamics (PK-PD) of propafenone (Pro) in healthy subjects. METHODS: Ten healthy Chinese volunteers, 5 extensive metabolizers (EM) and 5 intermedi...