新型减肥药利莫纳班的离子阱质谱和电子轰击质谱研究  

Study on Rimonabant by Ion Trap and EI Mass Spectrometry

作　　者：王宇晓[1] 许学书[1] 

机构地区：[1]华东理工大学生物反应器国家重点实验室,上海200237

出　　处：《分析测试学报》2007年第z1期50-52,共3页Journal of Instrumental Analysis

摘　　要：Rimonabant was studied by ESI ion trap mass spectrometry and EI(electron impact) time-of-flight mass spectrometry.m/z 380.9 can be used for identification of this drug by LC-MS.An exact mass at m/z 462.0782 (calculated 462.0781) with abundance (8.56%) in the spectra was found for its molecular ion.Ten characteristic fragment peaks with relatively strong intensities were observed,which can be used for identification of this drug.Rimonabant was studied by ESI ion trap mass spectrometry and EI(electron impact) time-of-flight mass spectrometry.m/z 380.9 can be used for identification of this drug by LC-MS.An exact mass at m/z 462.0782 (calculated 462.0781) with abundance (8.56%) in the spectra was found for its molecular ion.Ten characteristic fragment peaks with relatively strong intensities were observed,which can be used for identification of this drug.

关 键 词：RIMONABANT ESI Ion trap mass spectrometry EI Time of flight mass spectrometry 

分 类 号：O657-55[理学—分析化学]