细胞毒T淋巴细胞相关抗原4基因多态性与乳腺癌易感性的关联研究  

Association of cytotoxic T lymphocyte antigen-4 gene polymorphisms with susceptibility to breast cancer

作　　者：李恒[1] 傅振坤[1] 王丽虹[1] 李大林[1] 吴娜哈尔滨医科大学卫生微生物学教研室 章婕[1] 李殿俊[1] 

机构地区：[1]哈尔滨医科大学免疫学教研室 哈尔滨医科大学附属肿瘤医院 哈尔滨医科大学免疫学教研室 黑龙江哈尔滨 黑龙江哈尔滨,黑龙江哈尔滨150086

出　　处：《细胞与分子免疫学杂志》2008年第3期282-284,共3页Chinese Journal of Cellular and Molecular Immunology

基　　金：黑龙江省科技厅攻关资助项目(GB05C402-03)

摘　　要：目的:探讨CTLA-4基因多态性位点-1722T/C和CT60G/A与中国北方汉族妇女乳腺癌易感性的关系。方法:采用聚合酶链反应(PCR)和限制性片段长度多态性方法,对328例中国北方汉族乳腺癌患者和327例正常对照者进行CT-LA-4基因-1722位点和CT60位点多态性检测。结果:乳腺癌患者CTLA-4基因CT60位点G等位基因频率在乳腺癌患者组中明显高于正常对照组(28.7%比23.5%;P=0.0352,OR=1.30,95%CI=1.02~1.67);-1722C-CT60A单体型在对照组中的频率大于病例组中的频率,有明显差异(P=0.0283,OR=0.77,95%CI=0.97~0.61),而在-1722位点基因型频率、等位基因频率与对照组比较差异无统计学意义(P>0.05)。结论:CTLA-4基因多态性-1722和CT60两个位点与我国北方汉族妇女乳腺癌发病存在一定的相关性。AIM:To investigate the association between the CTLA-4 promoter-1722(T/C)and 3 untranslated region CT60(G/A)polymorphisms and the risk of breast cancer in Han women of northeast China.METHODS:328 patients with breast cancer and 327 healthy people as control were genotyped for-1722 and CT60 polymorphism using polymerase chain reaction and restriction fragment length polymorphism.RESULTS:The frequency of the G allele at the CT60 site in breast cancer patients was statistically higher than that in control(28.7...

关 键 词：乳腺癌 CTLA-4基因 单核苷酸多态性 单体型 

分 类 号：R737.9[医药卫生—肿瘤]