exosome的研究进展  

Progress in the Research of Exosome

作　　者：杜嘉瑞[1] 鞠砚[1] 

机构地区：[1]吉林大学第一附属医院神经外科,吉林长春130021

出　　处：《中国神经肿瘤杂志》2006年第4期276-285,共10页Chinese Journal of Neuro-Oncology

摘　　要：exosome是一种可由多种细胞分泌的纳米量级的膜性小囊泡。经研究后发现,其内含有独特的蛋白质与脂质。这也决定了exosome的生物学功用,如去除细胞生长过程中的废弃蛋白、抗原提呈、信号传导或诱导抗肿瘤免疫反应等。本文就exosome的研究进展做一综述,阐述到目前为止对exosome的生理组成及生物功能的研究成果,并探讨其在生物学应用方面的潜在前景。Exosomes are nanometer sized membrane vesicles secreted by a multitude of cells. The protein and lipid compositions are unique and this accounts for their biological functions. This review summarizes the composition and formation of exosome and its biological functions, such as eradication of obsolete proteins, antigen presentation, signal transduction and anti-tumor immune response.We present the recent development in the field of exosome research and the potential biological applications .

关 键 词：EXOSOME 生物来源 分子组成 生物学功能 

分 类 号：R730.2[医药卫生—肿瘤]