胰岛素抵抗高血压大鼠胰岛素抵抗和血清瘦素水平对血脂的影响  

Effects of Insulin Resistance and Serum Leptin Level on Serum Lipids in Insulin Resistant Hypertensive Rats

作　　者：赵旭燕[1] 李玉明[1] 王波[1] 

机构地区：[1]武警医学院附属医院心血管病研究所,天津市300162

出　　处：《中国动脉硬化杂志》2004年第6期656-658,共3页Chinese Journal of Arteriosclerosis

基　　金：天津市自然科学基金重点项目 (0 2 3 80 3 611)

摘　　要：用雄性Sprague Dawley大鼠建立胰岛素抵抗高血压大鼠模型 ,探讨胰岛素抵抗和血清瘦素水平的变化对血脂的影响。采用高果糖饲料喂雄性Sprague Dawley大鼠 ,观察其血压、胰岛素、瘦素和血脂水平的变化 ,用稳态模型评估胰岛素抵抗 ,并对上述指标进行相关性分析。结果发现 ,喂养 8周后 ,与对照组相比 ,模型组血压、血清胰岛素和胰岛素抵抗明显升高 ,血清瘦素、总胆固醇和甘油三酯水平升高 ,高密度脂蛋白降低。模型组中 ,胰岛素抵抗与血压、血清瘦素和甘油三酯呈显著正相关 ,与高密度脂蛋白呈显著负相关 ;血清瘦素与血压、血清胰岛素、胰岛素抵抗和甘油三酯呈显著正相关。结果提示 ,高果糖饲料可诱导雄性Sprague Dawley大鼠发生胰岛素抵抗、高血压、高瘦素血症和脂代谢紊乱 ,胰岛素抵抗和瘦素对脂代谢有广泛影响。Aim To establish insulin resistant hypertensive rat model and investigate the effects of insulin resistance and serum leptin level on serum lipids. Methods Male Spraque-Darley rats were fed on high fructose diet and the levels of blood pressure, serum insulin, leptin, triglyceride, total cholesterol and high density lipoprotein cholesterol were measured. The HOMA model was used to evaluate insulin resistance. The relationships between each parameters were analyzed. Results At the end of 8 weeks,in high fructose fed rats, blood pressure, serum insulin level and insulin resistance were significantly higher than those in control group, following hyperleptinemia and dislipidemia. In high fructose-fed rats, insulin resistance was positively related to blood pressure, serum leptin and triglyceride, while negatively to high-density lipoprotein-cholesterol. Also serum leptin was positively related to blood pressure, serum insulin,triglyceride and insulin resistance. Conclusions High fructose diet can induce insulin resistance, hypertension, hyperleptinemia and dislipidemia in male Spraque-Darley rats. Insulin resistance and leptin have a wide influence on lipids metabolism.

关 键 词：病理学与病理生理学 胰岛素抵抗高血压大鼠模型 动物实验 瘦素 甘油三酯 总胆固醇 高密度脂蛋白 

分 类 号：R363[医药卫生—病理学]