急性淋巴细胞白血病中肿瘤相关基因FGFR3 mRNA的表达及意义  

Expression of FGFR3 mRNA in Acute Lymphoblastic Leukemia and Its Clinical Significance

作　　者：吴静怡[1] 黄亮[1] 熊婕[1] 曹阳[1] 孙立石[1] 刘文励[1] 周剑峰[1] 

机构地区：[1]华中科技大学同济医学院附属同济医院血液内液,湖北武汉430030

出　　处：《中国血液流变学杂志》2008年第1期64-67,共4页Chinese Journal of Hemorheology

摘　　要：目的了解急性淋巴细胞白血病(ALL)中FGFR3基因的表达情况及其和临床的关系。方法采用RT-PCR法检测了58例ALL和16例正常对照骨髓样本中FGFR3 mRNA的表达情况,并分析其与临床指标、融合基因及染色体异常的相关性。结果FGFR3基因在ALL各型中均有表达,ALL组(48.28%)的FGFR3基因表达与正常对照(18.75%)相比差异有统计学意义(P<0.05),而各型相比阳性率差异无统计学意义(P>0.05)。FGFR3基因的阳性表达与患者年龄和外周血高白细胞计数(≥25×109/L)呈显著性正相关(P<0.05)。ALL患者中FGFR3基因的表达与Bcr/Abl融合基因及其对应染色体异常t(9;22)均呈显著相关性(P<0.05)。结论ALL中FGFR3基因的过表达提示其很可能参与了ALL的发病。Objective To explore FGFR3 gene expression and its clinical significance in acute lymphoblastic leukemia (ALL).Methods The expression levels of FGFR3 mRNA in 58 patients with acute lymphoblastic leukemia including ALL1 (12 cases),ALL2 (42 cases),ALL3 (4 cases) and 16 normal controls were assayed by RT-PCR. Results FGFR3 gene was detected in ALL1,ALL2 and ALL3.The positive expression ratio of FGFR3 mRNA in ALL (48.28%) was significantly higher than that in normal control (P<0.05).The increased level of FG...

关 键 词：急性淋巴细胞白血病 FGFR3 聚合酶链反应 

分 类 号：R733.7[医药卫生—肿瘤]