食管鳞状细胞癌患者单个核细胞Th类细胞因子表达的临床意义  

The expression of Th type cytokines by peripheral blood in the patients with esophageal squamous cell

作　　者：石殿鹏[1] 李道堂[1] 张百江[1] 王国范[1] 王颖[2] 

机构地区：[1]山东省肿瘤医院,山东济南250062 [2]山东省医学科学院附属医院

出　　处：《山东医药》2002年第31期8-9,共1页Shandong Medical Journal

摘　　要：为探讨外周血单个核细胞(PBMC)Th_1、Th_2类细胞因子的表达与食管鳞状细胞癌病理因素之间的关系,采用双抗体酶联免疫吸附法(ELISA)检测39例食管鳞状细胞癌患者外周血Th_1、Th_2类细胞因子的含量水平,同时以20例正常人作为健康对照。结果显示,食管鳞状细胞癌患者PBMC中IL-2、INF-γ表达明显低于对照组(P<0.05),IL-6表达明显高于对照组(P<0.05),存在Th_1/Th_2漂移现象;且TNM分期越晚,Th_1类细胞因子IL-2表达越弱,IL-6表达越强,存在显著差异性(P<0.05)。Th_1/Th_2漂移现象与肿瘤分化程度无明显相关性。提示食管鳞状细胞癌患者PBMC存在Th_2细胞优势,而Th_1类细胞因子表达减弱;Th_1/Th_2漂移现象与肿瘤的TNM分期有关。To study the relationship of the expression of Th_1/Th_2 type cytokines by peripheral blood in thepatients with esophageal squamous cell cancer and its pathologic factors, we used the enzyme linkedimmunosorbent assay (ELISA) to detect the expression of Th_1(IL-2 and INF-γ) and Th_2(IL-4,IL-6 and IL-10)type cytokine in 20 controls and 39 patients with esophageal squamous cell carcinoma. Th_1/Th_2 shift exists in thepatients with esophageal squamous cell cancer, levels of Th_1 type cytokines are significantly...

关 键 词：食管鳞状细胞癌 血清 Th_1/Th_2漂移 

分 类 号：R735.1[医药卫生—肿瘤]