supported by the National Natural Science Foundation of China(No.82070238);the Natural Science Foundation of Chongqing(No.CSTB2022NSCQ-MSX0913);the China Postdoctoral Science Foundation(No.2022M720601);the Postdoctoral Natural Science Foundation of Chongqing(No.2022CQBSHTBT003);Program for Youth Innovation in Future Medicine,Chongqing Medical University(No.W0168);the Postdoctoral Incubation Project of the First Affiliated Hospital of Chongqing Medical University(No.CYYY-BSHPYXM-202204)。