Effect of rhBMP-2m on c-Myb gene expression in bone marrow of irradiated mice  

作　　者：陈衍 田琼 杨岚 张绍章 朱帮福 于文强 陈苏民 

出　　处：《Journal of Medical Colleges of PLA(China)》2001年第3期223-226,共4页中国人民解放军军医大学学报（英文版）

基　　金：SupportedbyNationalNaturalScienceFoundationofChina(No.39970231)

摘　　要：Objective:To exploretheexpressionof c-Mybgenein thebonemarrowcellof irradiatedmicetreated with rhBMP-2manditssignificance.Methods:By wayof RT-PCRandRNAdotblot,we observedtheexpressionof c-Myb geneinthebonemarrowcellsof micetreateddifferentlyon day10andday20afterirradiationrespectively.Results:On day10afterirradiation,theexpressionof c-Mybgeneinthebonemarrowcellof irradiatedmicetreatedwithrhBMP-2mis evidentlyhigherthanthatinnormalmice,andalsohigherthanthatonlytreated withirradiation.However,on day20after irradiation,thereareno evidentdifferencesin thethreegroups.Con clusion:c-Mybgenetakespartin therecoveryof hematopoiesisduringthestageof acuterecoveryinbonemarrow afterirradiation,andtheeffectis enhancedinthepartici-pationof rhBMP-2m.Objective:To exploretheexpressionof c-Mybgenein thebonemarrowcellof irradiatedmicetreated with rhBMP-2manditssignificance.Methods:By wayof RT-PCRandRNAdotblot,we observedtheexpressionof c-Myb geneinthebonemarrowcellsof micetreateddifferentlyon day10andday20afterirradiationrespectively.Results:On day10afterirradiation,theexpressionof c-Mybgeneinthebonemarrowcellof irradiatedmicetreatedwithrhBMP-2mis evidentlyhigherthanthatinnormalmice,andalsohigherthanthatonlytreated withirradiation.However,on day20after irradiation,thereareno evidentdifferencesin thethreegroups.Con clusion:c-Mybgenetakespartin therecoveryof hematopoiesisduringthestageof acuterecoveryinbonemarrow afterirradiation,andtheeffectis enhancedinthepartici-pationof rhBMP-2m.

关 键 词：C-MYB gene RHBMP-2M ACUTE radiation INJURY 

分 类 号：R394[医药卫生—医学遗传学]