Cyclin D3与Ki-67在涎腺腺泡细胞癌中的表达及意义  

Study on the expression of cyclin D3 and Ki-67 in salivary gland acinic cell carcinoma

作　　者：贾祝强[1] 张福胤[1] 

机构地区：[1]大连医科大学附属第一医院口腔科,辽宁大连116011

出　　处：《中国医疗前沿（学术版）》2008年第6期17-19,共3页China Healthcare Innovation

摘　　要：目的研究cyclin D3和Ki-67在ACC中的表达情况及意义。方法采用免疫组织化学法,分别检测cyclin D3和Ki-67蛋白在10例正常涎腺组织(NSG)及34例ACC组织标本中的表达情况。结果Cyclin D3LI在ACC组高于NSG组(P<0.05)。复发组的cyclin D3LI高于无复发组(P<0.05)。Ki-67LI在ACC组明显高于NSG组(P<0.05)。小涎腺组的Ki-67LI低于腮腺组显著性(P<0.05)。Ki-67LI在复发组高于无复发组(P<0.05)。在ACC中cyclin D3的表达与Ki-67的表达呈正相关(r=0.392,P<0.05)。结论Cyclin D3的表达在ACC的发展过程中有一定作用,促进了细胞增殖,并可能与复发有关。Ki-67可能是一个重要的ACC预后因子。ObjectiveThe aim of the present study is to investigate the expression of cyclin D3 and Ki-67 in ACCs.Methods The SP immunohistochemical method was used to detect the expression of cyclin D3 and Ki-67 in 34 cases of ACC and 10 cases of normal salivary gland(NSG).Results The label index (LI) of cyclin D3 was higher in ACC group than that in NSG (P < 0.05). Cyclin D3 LI was significantly different between recurrence group and no recurrence group (P < 0.05). The LI of Ki-67 was significantly higher in ACC group than that in NSG (P < 0.05). The LI of Ki-67 in minor salivary gland ACC was lower than that in parotid gland ACC (P < 0.05). The LI of Ki-67 had a significant difference between recurrence group and no recurrence group (P < 0.05). The expression of cyclin D3 had a positive correlation with that of Ki-67 (P < 0.05).Conclusion The expression of Cyclin D3 might play certain roles in accelerating the progress of cell cycle and promoting cell proliferation . Cyclin D3 expression also related with the recurrence of ACC in our stdudy. Ki-67 appears to be a significant prognostic factor in ACC.

关 键 词：涎腺 腺泡细胞癌 细胞周期 CYCLIN D3 KI-67 

分 类 号：R739.87[医药卫生—肿瘤]