应用组织芯片研究sialyl Lewis^x和CD44v6在结肠癌中的表达及意义  

Application of Tissue Microarray to Study the Expression of sialyl Lewis^X and CD44v6 in Colon Carcinoma and Its Significance

作　　者：孙守毅[1] 胡小云[2] 张文昌[3] 李里香[3] 雷英[3] 李从于[4] 

机构地区：[1]南昌大学研究生院医学部,2006级南昌330006 [2]南昌大学第二附属医院胃肠外科,南昌330006 [3]南昌大学第二附属医院病理科,南昌330006 [4]宁都县人民医院外科,江西宁都332600

出　　处：《江西医学院学报》2009年第5期25-28,140,共5页Acta Academiae Medicinae Jiangxi

摘　　要：目的应用组织芯片研究sialyl Lewisx和CD44v6在结肠癌中的表达及意义。方法应用组织芯片技术和免疫组化技术,检测103例结肠癌组织中sialyl Lewisx和CD44v6的表达,并结合肿瘤的病理学指标和临床随访资料进行分析。结果结肠癌中sialyl Lewisx和CD44v6阳性表达率分别为83.5%和82.5%,且晚期结肠癌明显高于早、中期结肠癌(P<0.05);sialyl Lewisx和CD44v6表达具有一致性,且与结肠癌的临床分期、浸润程度、淋巴结及远处转移和预后有关(P<0.05)。结论sialyl Lewisx和CD44v6的表达与结肠癌转移和患者生存期密切相关,联合检测sialyl Lewisx和CD44v6在结肠癌中的表达对于判断其恶性程度、预测生物学行为和评估患者预后具有重要意义。Objective To explore the expression of sialyl LewisX and CD44v6 in colon carcinoma and its significance.Methods The expression of sialyl LewisX and CD44v6 were detected by tissue microarray and immunohistochemical method in 103 colon carcinomas.The relationship was analyzed between the expression of sialyl LewisX and CD44v6 and the clinicopathological factors.Results The positive expression rate of sialyl LewisX and CD44v6 in colon carcinoma were 83.7% and 82.7% respectively.The positive expression rate of ...

关 键 词：组织芯片 SIALYL LEWISX CD44V6 结肠癌 

分 类 号：R735.35[医药卫生—肿瘤]