CPT-11联合5-FU/FA方案治疗局部晚期或转移性结直肠癌的临床研究  被引量：9

inical study of CPT-11 combined with 5-FU/FA policy in patients with advanced or metastatic colorectal cancer</em> <p class='article-op'> <span id="bdshare" class="bdshare_t bds_tools get-codes-bdshare baidufx"><span><span class="bds_more" style="display: block; width: 62px; height: 29px; background: url(/images/share.gif) no-repeat!important; padding: 0;"></span></span></span> </p> <p class="article-source"> <a href ='/article/read.aspx?id=1001083401' class='btnTitle btnIsView' target='_blank'><img alt='在线阅读' src='/images/btn-read.png'/></a><a class='btnTitle btnIsView' href="javascript:showdown('L/TRNcl+RJtyfpCqhi2yCHAyd9oTNp4eFg2v5eEFQVrZellgGxSw+Q==')"><img alt="下载全文" src="/images/btn-down.png" /></a> <input id="hiddowninfo" type="hidden" value="L/TRNcl+RJtyfpCqhi2yCHAyd9oTNp4eFg2v5eEFQVrZellgGxSw+Q=="/> </p> <div class="collect" style="display: none"> <h5>我的收藏</h5> <div class="cnt"> <p> 名 称：<input type="text" name="collTitle" id="collSumTitle" /> </p> <p> 注 释：<input type="text" name="collRemark" id="collSumRemark" /> </p> <p style="text-align: center;"> <a href="javascript:void(0)" onclick="g_collectSumOk();"> <img width="65" height="17" src="/images_new/collect_ok.png" alt="完成" /></a> <a href="javascript:void(0)" onclick="g_collectSumCancel();"> <img width="65" height="17" src="/images_new/collect_no.png" alt="取消" /></a> </p> </div> </div> </div> <form name="wxTransfer" method="post"> <input type="hidden" name="lid" value="" /> <input type="hidden" name="sip" value="" /> <input type="hidden" name="date" value="" /> <input type="hidden" name="co" value="" /> <input type="hidden" name="Title_C" value="" /> <input type="hidden" name="Writers" value="" /> <input type="hidden" name="Name_C" value="" /> <input type="hidden" name="Num" value="" /> <input type="hidden" name="Years" value="" /> <input type="hidden" name="Volumn" value="" /> <input type="hidden" name="GCH" value="" /> <input type="hidden" name="Vol" value="" /> <input type="hidden" name="BookID" value="" /> <input type="hidden" name="SubjectNum" value="" /> <input type="hidden" name="SpecialNum" value="" /> <input type="hidden" name="mirrorName" value="" /> <input type="hidden" name="UserID" value="" /> <input type="hidden" name="UserName" value="" /> <input type="hidden" name="sourceID" value="" /> </form> <script type="text/javascript" src="/scripts/transfer.min.js"></script> <div class="article-detail"> <p class='author'><strong>作　　者：</strong><a href='/writer/article.aspx?id=100000000464181' target='_blank' ><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=A%3d%5b%e6%a8%8a%e9%9d%92%e9%9c%9e%5d' title='樊青霞[1]'>樊青霞[1]</a> <a href='/writer/article.aspx?id=100000006382363' target='_blank' ><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=A%3d%5b%e5%90%b4%e6%ac%a3%e7%88%b1%5d' title='吴欣爱[1]'>吴欣爱[1]</a> <a href='/writer/article.aspx?id=100000007719516' target='_blank' ><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=A%3d%5b%e7%8e%8b%e7%95%99%e5%85%b4%5d' title='王留兴[1]'>王留兴[1]</a> <a href='/writer/article.aspx?id=100000005914873' target='_blank' ><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=A%3d%5b%e7%8e%8b%e7%91%9e%e6%9e%97%5d' title='王瑞林[1]'>王瑞林[1]</a> <a href='/writer/article.aspx?id=100000007801734' target='_blank' ><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=A%3d%5b%e8%8c%83%e9%ad%81%e7%94%9f%5d' title='范魁生[1]'>范魁生[1]</a> <a href='/writer/article.aspx?id=100000013503799' target='_blank' ><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=A%3d%5b%e8%ae%b8%e8%8e%89%5d' title='许莉[1]'>许莉[1]</a> <a href='/writer/article.aspx?id=100000006069339' target='_blank' ><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=A%3d%5b%e8%b7%af%e5%b9%b3%5d' title='路平[2]'>路平[2]</a> <a href='/writer/article.aspx?id=100000009032050' target='_blank' ><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=A%3d%5b%e5%88%98%e6%b9%98%e5%ae%81%5d' title='刘湘宁[3]'>刘湘宁[3]</a> <em> </em></p><p class='organ'><strong>机构地区：</strong><a href='/organ/article.aspx?id=2527&subid=&showname=&searchtype=' target='_blank'><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=S%3d%e9%83%91%e5%b7%9e%e5%a4%a7%e5%ad%a6%e7%ac%ac%e4%b8%80%e9%99%84%e5%b1%9e%e5%8c%bb%e9%99%a2%e8%82%bf%e7%98%a4%e7%a7%91' title='[1]郑州大学第一附属医院肿瘤科,郑州450052'>[1]郑州大学第一附属医院肿瘤科,郑州450052</a> <a href='/organ/article.aspx?id=2557645&subid=&showname=&searchtype=' target='_blank'><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=S%3d%e6%96%b0%e4%b9%a1%e5%8c%bb%e5%ad%a6%e9%99%a2%e9%99%84%e5%b1%9e%e5%8c%bb%e9%99%a2%e8%82%bf%e7%98%a4%e7%a7%91' title='[2]新乡医学院附属医院肿瘤科'>[2]新乡医学院附属医院肿瘤科</a> <a href='/organ/article.aspx?id=58124&subid=&showname=&searchtype=' target='_blank'><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=S%3d%e4%b8%ad%e5%9b%bd%e4%ba%ba%e6%b0%91%e8%a7%a3%e6%94%be%e5%86%9b' title='[3]中国人民解放军153医院外科'>[3]中国人民解放军153医院外科</a> <em> </em></p><p class='from'><strong>出　　处：</strong><a href='/journal/summary.aspx?gch=88329X' target='_blank'><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=J%3d%5b%e7%99%8c%e7%97%87%e8%bf%9b%e5%b1%95%5d' title='癌症进展'>《癌症进展》</a>2004年第6期478-481,共4页<em>Oncology Progress</em></p><p class='abstrack'><strong>摘　　要：</strong>目的 评价CPT-11(开普拓)联合5-FU／FA治疗局部晚期或转移性结直肠癌的临床疗效及不良反应。方法 符合收治标准者19例,可评价疗效者17例,入组Arm A方案8例,Arm B方案9例,ArmA方案:CP-11 270mg/m2静滴d1;FA200mg／m2,5-FU 425mg／m2分别静滴,均d1-5,每3周重复,两次CPT-11(6周)评价疗效。ArmB方案:CPT-11 180mg/m2静滴d1,LA200mg/m2,静滴d1-2,5-FU 400mg／m2静推,然后5-FU 600mg／m2,d1-2,每2周重复,应用3次CPT-11(6周)为一个周期。结果 17例患者,CR 1例,PR 5例,SD 9例,PD 2例,总缓解率35％,稳定率52.9％,中位缓解时间7.5个月,中位稳定时间5个月。主要剂量限制毒性为迟发性腹泻及中性粒细胞减少。结论 CPT-11联合5-FU／FA两种方案治疗局部晚期或转移性结直肠癌有较高的疾病缓解率和稳定率,主要剂量限制毒性为迟发性腹泻及中性粒细胞减少。<em><abstract>iective To evaluate the clinical efficacy and adverse effects of irrinotecan(CPT-11) combined with FU/FA in the treatment of advanced or metastatic colorectal cancer. Methods Ninteen cases of metastatic colorectal cancer patients were treated, and 17cases were evaluahle for eaicacy. Of Which 8 cases were grouped with Arm A policy and 9 cases were grouped with Arm B policy. Arm A policy: CPT-11 270mg/m2 ivgtt d1; FA 200mg/m2 ivgtt d1-5; 5-FU 425mg/m2 d1-5, every 3 weeks repeated, a cycle was 6 weeks. Arm B: CPT-11 180mg/m2 ivgtt d1, LA200mg/m2 ivgtt follow by 5-FU 400mg/m2 iv and 5-FU 600mg/m2 ivgtt d1, 2 every 2 weeks repeated, a cycle was 6 weeks. Results In 17 evaluabfle patients, one case had completeresponse, 5 cases had partial response, 9 cases had stable disease and 2 with progressive disease. The Response rate of the whole groups was 35.0% and the stable rate was 52.9% . Dose limting toxicity (DLT) was delayed diarrhea and neutropenia. Conclusion The two policy of CPT-11 combined with FU/FA had higher response rate and stable rate in treatment metastatic colorectal cancer. Main DLT are delayed diarrhea and neutropenia .</em></p><p class='subject'><strong>关 键 词：</strong><a href='/subject/article.aspx?id=4919540' target='_blank'><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=K%3d%5b%e7%bb%93%e7%9b%b4%e8%82%a0%e7%99%8c%5d' title='结直肠癌'>结直肠癌</a> <a href='/subject/article.aspx?id=8308387' target='_blank'><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=K%3d%5bCPT-11%5d' title='CPT-11'>CPT-11</a> <a href='/zk/search.aspx?key=K%3d%5b%e4%b8%b4%e5%ba%8a%e7%a0%94%e7%a9%b6%5d' title='临床研究'>临床研究</a> <a href='/subject/article.aspx?id=5471206' target='_blank'><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=K%3d%5b%e5%8c%96%e7%96%97%5d' title='化疗'>化疗</a> </p><p class='class'><strong>分 类 号：</strong><a href='/zk/search.aspx?key=C%3dR735.3%2b4' title='R735.3+4'>R735.3+4</a>[<a href = '/domain/article.aspx?id=503' >医药卫生—肿瘤</a>] </p> </div> <div id="content_wzxg" name="wzxg" class="article-graph"> <object width="695" height="250" classid="clsid:D27CDB6E-AE6D-11cf-96B8-444553540000" id="FlashID"> <param value="../flash/relation.swf" name="movie"> <param value="high" name="quality"> <param value="opaque" name="wmode"> <param value="6.0.65.0" name="swfversion"> <param value="dataUrl=/ajax/articlerelativegraph.ashx?id=1001083401" name="flashVars"> <embed width="695" height="250" src="../flash/relation.swf" type="application/x-shockwave-flash" quality="high" wmode="opaque" flashvars="dataUrl=/ajax/articlerelativegraph.ashx?id=1001083401"> </embed> </object> </div> <div class="article-relate-list"> <div class="relate-list"> <p id="ckwx_br"> </p> <h2 name="ckwx" id="ckwx">参考文献：</h2> <div id="listckwx"> <p class='submit'> <img src='/images/loading.gif' width='16' height='16' /> 正在载入数据... </p> </div> </div> <div class="relate-list"> <p id="2jckwx_br"> </p> <h2 name="2jckwx" id="2jckwx">二级参考文献：</h2> <div id="list2jckwx"> <p class='submit'> <img src='/images/loading.gif' width='16' height='16' /> 正在载入数据... </p> </div> </div> <div class="relate-list"> <p id="ohwx_br"> </p> <h2 name="ohwx" id="ohwx">耦合文献：</h2> <div id="listohwx"> <p class='submit'> <img src='/images/loading.gif' width='16' height='16' /> 正在载入数据... </p> </div> </div> <div class="relate-list"> <p id="yzwx_br"> </p> <h2 name="yzwx" id="yzwx">引证文献：</h2> <div id="listyzwx"> <p class='submit'> <img src='/images/loading.gif' width='16' height='16' /> 正在载入数据... </p> </div> </div> <div class="relate-list"> <p id="2jyzwx_br"> </p> <h2 name="2jyzwx" id="2jyzwx">二级引证文献：</h2> <div id="list2jyzwx"> <p class='submit'> <img src='/images/loading.gif' width='16' height='16' /> 正在载入数据... </p> </div> </div> <div class="relate-list"> <p id="tbywx_br"> </p> <h2 name="tbywx" id="tbywx">同被引文献：</h2> <div id="listtbywx"> <p class='submit'> <img src='/images/loading.gif' width='16' height='16' /> 正在载入数据... </p> </div> </div> <div class="relate-list"> <p id="xgqklw_br"> </p> <h2 name="xgqklw" id="xgqklw">相关期刊文献：</h2> <div id="listxgqklw"> <p class='submit'> <img src='/images/loading.gif' width='16' height='16' /> 正在载入数据... </p> </div> </div> </div> </div> <div class="article-about"> <div class="about-box"> <h5 class="name">相关的主题<tt><a class="hide" href="#"></a></tt></h5> <div class="about-list"> </div> </div> <div class="about-box"> <h5 class="name">相关的作者对象<tt><a class="" href="#"></a></tt></h5> <div class="about-list" style="display: none;"> </div> </div> <div class="about-box"> <h5 class="name">相关的机构对象<tt><a class="" href="#"></a></tt></h5> <div class="about-list" style="display: none;"> </div> </div> </div> </div> </div> <script type="text/javascript" src="/scripts/articlerelation.min.js"></script> <script type="text/javascript" src="/scripts/articlerightrelation.min.js"></script> <script type="text/javascript" src="/scripts/articledown.min.js"></script> <div class="layer-box download" id="downloadlayer" style="display: none"> <div class="close"> <a onclick="closedown()" href="javascript:void(0)"> <img src="/images/layer-close.png" width="21" height="21" alt="" /> </a> </div> <h5 class="layer-title">下载全文</h5> <div id="downloadinfo"></div> </div> <div class="layer-box download" id="downloadlayer2" style="display:none;min-height:100px;width:500px;"> <p> <img src="/images/loading2.gif" width="64" height="64"> <span style="font-size:20px;vertical-align:middle;padding-bottom:50px;">正在链接到云南高校图书馆文献保障联盟下载...</span> </p> </div> <script id="bdshare_js" data="type=tools&uid=0" type="text/javascript"></script> <script type="text/javascript"> $(function () { var rd = GetQueryString("rd"); if (rd == "readdown") { var val = $("#hiddowninfo").val(); showdown(val); } $("#bdshare_js").attr("src","http://bdimg.share.baidu.com/static/js/bds_s_v2.js?cdnversion="+Math.ceil(new Date() / 3600000)); }) </script> <div class="layer-bg" style="display: none;"></div> <script type="text/javascript" src="/scripts/login.min.js"></script> <div class="layer-box login" id="divLoginBox" style="display: none;"> <div class="close"><a href="javascript:void(0);" id="btnLoginClose"> <img src="/images/layer-close.png" width="21" height="21" alt="" title="关闭" /></a></div> <h5 class="layer-title">用户登录</h5> <div class="layer-cnt"> <div class="search-list adv-object"> <div class="login-alert" id="divLoginError"></div> <div class="sinput"> <div class="input"><span class="user-ico"></span> <input type="text" id="txtLUsername" name="txtLUsername" maxlength="20"></div> </div> <div class="sinput"> <div class="input"><span class="psw-ico"></span> <input type="password" id="txtLPassword" name="txtLPassword" maxlength="20"></div> </div> <div class="submit"> <input type="button" value="登录" onclick="return normalLogin(loginAfter)" name="" class="btn-s"><input value="IP登录" onclick=" return ipLogin(loginAfter)" type="button" class="btn-c"> </div> </div> </div> </div> <div id="footer"> <p> 云南高校图书馆联盟文献共享服务平台 版权所有© <script type="text/javascript"> document.write(new Date().getFullYear()); </script> </p> <p> 您的IP：216.73.216.3 </p> </div> <input id="hifBaseLog" type="hidden" value="ODgzMjlYOzEwMDEwODM0MDE7UjczNS4zKzQ7MDs7L2FydGljbGUvZGV0YWlsLmFzcHg="/> <script type="text/javascript"> $(document).ready(function () { $("#loginLoading").load("/user/loginheader.aspx?" + Math.random()); }); </script> <script> var _hmt = _hmt || []; (function () { var hm = document.createElement("script"); hm.src = "//hm.baidu.com/hm.js?36a05ff8f5e8a5be3ff03e1d75c8a9d1"; var s = document.getElementsByTagName("script")[0]; s.parentNode.insertBefore(hm, s); })(); </script> <script> (function (i, s, o, g, r, a, m) { i['GoogleAnalyticsObject'] = r; i[r] = i[r] || function () { (i[r].q = i[r].q || []).push(arguments) }, i[r].l = 1 * new Date(); a = s.createElement(o), m = s.getElementsByTagName(o)[0]; a.async = 1; a.src = g; m.parentNode.insertBefore(a, m) })(window, document, 'script', '//www.google-analytics.com/analytics.js', 'ga'); ga('create', 'UA-2219013-37', 'auto'); ga('send', 'pageview'); </script> </body> </html>