Effect of early correction of anemia with erythropoietin on left ventricular mass in predialysis patients:a multi-center trial  

作　　者：Fanfan HOU Jianping JIANG Lizhen GAO Yangbin PAN Niansheng YANG Wei CHEN Guiyang SHU Youming CHEN Jian CHEN Weihua PENG Jianping WU Zhongmin YANG 

机构地区：[1]Division of Nephrology,Nanfang Hospital,Guanzhou 510515,China

出　　处：《Journal of Geriatric Cardiology》2005年第3期136-139,共4页老年心脏病学杂志(英文版)

摘　　要：Objective To assess the effects of early correction of anemia with recombinant human erythropoietin(rHuEPO)on the development and progression of left ventricular hypertrophy(LVH)in patients with mild-to-moderate chronic renal insufficiency(CRI)who are not on hemodialysis.Methods A total of 158 patients with serum creatinine from 147μmol/L to 400μmol/L were nrolled in this prospective,multicenter study.Eighty-six patients with hemoglobin(Hb)<110g/L received rHuEPO treatment with a target Hb of≥110g/L(Group A).Forty patients with comparable Hb concentration(<110g/L)but did not receive rHuEPO(Group B)and 32 patients with Hb≥110g/L and without rHuEPO treatment(Group C)were served as controls.Left ventricular mass index(LVMI)was evaluated by echocardiography at baseline and every 3 months for 2 years.Results There was no difference in age,gender,etiology of renal failure,blood pressure and cardiovascular risk factors among the 3 groups.At baseline,the prevalence of LVH was 72.1%in group A,72.5%in group B and 59.4%in group C.LVMI was inversely correlated with Hb levels(r=0.70,P<0.01).During the 2-year period,the mean LVMI decreased from 142.6±25.7g/m^(2)to 132.4±18.5 g/m^(2)in group A,while increased significantly in both group B and group C.The mean Hb concentration increased from 93.8±14.6g/L to 111.2±10.3g/L(P<0.05)in group A,but tended to decrease in group B and group C.There was no significant change of the mean blood pressure,number of anti-hypertensive drugs and serum creatinine concentrations in all 3 groups.However,patients'serum creatinine doubled more often in group B and group C than in group A.Conclusions LVH was common in predialysis CRI patients and was associated with the severity of anemia.Early intervention with rHuEPO may reverse LVH in these patients.

关 键 词：renal failure CHRONIC ANEMIA left ventricular hypertrophy ERYTHROPOIETIN 

分 类 号：R[医药卫生]