普洱茶调节SD大鼠血脂及保护血管内皮的研究  

Effects of Pu-erh Tea on Hyperlipidemia,Antioxidation and Vascular Endothelium Protection in SD Rats

作　　者：徐湘婷[1] 王鹏[1] 罗绍忠[1] 侯艳[2] 杨继红[1] 邵宛芳[2] 

机构地区：[1]昆明医学院云南省天然药物药理重点实验室,云南昆明650500 [2]云南农业大学龙润普洱茶学院,云南昆明650201

出　　处：《茶叶科学》2010年第6期470-474,共5页Journal of Tea Science

基　　金：国家科技支撑计划课题子课题资助(2007BAD58B04-4)

摘　　要：采用治疗性给予普洱茶的方法,探讨普洱茶调节血脂、保护血管内皮及抗动脉粥样硬化的作用和机制。通过SD大鼠高脂饲料造模28d后,给予不同剂量普洱茶35d。试验期间检测所有动物的体重变化;试验结束后检测血脂水平及血浆一氧化氮(NO),并进行主动脉病理组织学检查。结果表明,普洱生茶及熟茶组与模型组比较:(1)体重明显减轻;(2)血清总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)明显降低,血浆NO浓度增加;(3)主动脉血管壁内皮细胞损伤减轻,血管内皮素-1(ET-1)表达减少。通过研究认为,治疗性给予普洱茶,能够降低高脂饲料饲喂SD大鼠的体重及血脂水平,熟茶作用更显著;普洱茶具有保护血管内皮的作用,其作用机制可能与它促进NO合成,抑制ET-1合成有关。To explore the effects and mechanisms of Pu-erh tea on hyperlipidemia treatment,antioxidation,vascular endothelium protection and artherosclerosis prevention.Hyperlipidemia were successfully induced in SD rats.Different doses of Pu-erh tea were administered to these rats for 35 days started from the 28th day of induction.Body weights of all animals were recorded during experiment.At the experimental endpoint,blood lipid levels and plasma NO levels were measured.Moreover,aortas of rats were collected to exam...

关 键 词：普洱茶 NO ET-1 高脂血症 血管内皮 

分 类 号：R151[医药卫生—营养与食品卫生学]