Effects of moxibustion on dynorphin and endomorphin in rats with chronic visceral hyperalgesia  

作　　者：Hui-Rong Liu  Li Qi  Lu-Yi Wu  Xiao-Peng Ma  Xiu-Di Qin  Wen-Yan Huang  Ming Dong  Huan-Gan Wu 

机构地区：[1]Key Laboratory of Acupuncture-Moxibustion and Immunological Effects,Shanghai University of Traditional Chinese Medicine,Shanghai 200030,China

出　　处：《World Journal of Gastroenterology》2010年第32期4079-4083,共5页世界胃肠病学杂志（英文版）

基　　金：Supported by The National Basic Research Program of China,973 Program,No 2009CB522900;Scientific Research Grants of Shanghai Health Bureau,No 2009209;Shanghai Leading Academic Discipline Project,No S30304

摘　　要：AIM:To observe the analgesic effects of moxibustion in rats with chronic visceral hyperalgesia and its influence on the concentration of dynorphin(Dyn) and endomorphin(EM) in spinal cord.METHODS:The rat model of chronic visceral hyperalgesia was established by colorectal distention(CRD).In moxibustion(MX) group,moxibustion was applied once daily for 7 d;in sham moxibustion(SM) group,moxibustion was given to the same acupoints but with the nonsmoldered end of the moxa stick.Model control(MC) group and normal control group were also studied.The scoring system of abdominal withdrawal reflex was used to evaluate visceral pain for behavioral assessment.Enzyme linked immunosorbent assay was performed to determine the concentrations of Dyn and EM in spinal cord.RESULTS:Moxibustion significantly decreased visceral pain to CRD in this rat model,and no significant difference was detected between the SM group and the MC group.In MX group,moxibustion also increased the concentrations of Dyn and EM in spinal cord,and no significant difference was found between the SM group and the MC group.CONCLUSION:Moxibustion therapy can significantly enhance the pain threshold of rats with chronic visceral hyperalgesia,and the effect may be closely related to the increased concentration of Dyn and EM in spinal cord.AIM:To observe the analgesic effects of moxibustion in rats with chronic visceral hyperalgesia and its influence on the concentration of dynorphin(Dyn) and endomorphin(EM) in spinal cord.METHODS:The rat model of chronic visceral hyperalgesia was established by colorectal distention(CRD).In moxibustion(MX) group,moxibustion was applied once daily for 7 d;in sham moxibustion(SM) group,moxibustion was given to the same acupoints but with the nonsmoldered end of the moxa stick.Model control(MC) group and normal control group were also studied.The scoring system of abdominal withdrawal reflex was used to evaluate visceral pain for behavioral assessment.Enzyme linked immunosorbent assay was performed to determine the concentrations of Dyn and EM in spinal cord.RESULTS:Moxibustion significantly decreased visceral pain to CRD in this rat model,and no significant difference was detected between the SM group and the MC group.In MX group,moxibustion also increased the concentrations of Dyn and EM in spinal cord,and no significant difference was found between the SM group and the MC group.CONCLUSION:Moxibustion therapy can significantly enhance the pain threshold of rats with chronic visceral hyperalgesia,and the effect may be closely related to the increased concentration of Dyn and EM in spinal cord.

关 键 词：MOXIBUSTION ANALGESIA HYPERSENSITIVITY DYNORPHINS ENDOMORPHIN 

分 类 号：R402[医药卫生—临床医学]