Supported by 973 Program:the Research of Law and Principle of Moxibustion(No.2009CB522905)
OBJECTIVE:To observe the influence of different moxibustion durations on hypothalamic pro-opiomelanocortin(POMC)and prodynorphin(PDYN)mRNA expressions and plasmaβ-endorphin(β-EP)content in rheumatoid arthritis(RA)ra...
supported by the National Basic Research Program of China(Nos.2007CB512501,2009CB522003).
Drug addiction is a chronic brain disorder characterized by withdrawal symptoms that occur during drug abstinence and a high tendency of relapse.Compared with the currently available pharmacological interventions,acup...
Supported by The National Basic Research Program of China,973 Program,No 2009CB522900;Scientific Research Grants of Shanghai Health Bureau,No 2009209;Shanghai Leading Academic Discipline Project,No S30304
AIM:To observe the analgesic effects of moxibustion in rats with chronic visceral hyperalgesia and its influence on the concentration of dynorphin(Dyn) and endomorphin(EM) in spinal cord.METHODS:The rat model of chron...
Project supported by the National Natural Science Foundation of China, № 39670829; Key Laboratory of Neuroscience, Shanghai Institute of Physiology, Chinese Academy of Sciences.
AIM:To study that l-stepholidine(SPD) regulates the expression of proenkephalin (PENK) and prodynorphin (PDYN) mRNA and Fos in the striatum after rotational test in the 6-hydroxydopamine (6-OHDA)-lesioned rats. METHOD...
To construct the 3D-structural model of human kappa opioid receptor (HKOR) and study its interacting mechanism with dynorphin A( 1 - 8) (Dyn8). METHODS: Comparative molecular modeling was applied to build the 7 transm...
It has been proved that endogenous opioids play an important pathophysiological role inthe lesions secondary to central nervous system trauma.Opiate antagonists and opioid antisera havebeen found to improve the outcom...