云南高校图书馆联盟文献共享服务平台- STEPHOLIDINE

STEPHOLIDINE: 作品数：15被引量：34H指数：4; 导出分析报告; 相关领域：医药卫生更多>>; 相关作者：金国章岳小芳徐昕红邱梅红黄志力更多>>; 相关机构：中国科学院复旦大学上海医学院上海医科大学核医学国家重点实验室更多>>; 相关期刊：《Science China(Life Sciences)》《Acta Pharmacologica Sinica》《Science China Chemistry》《中国药理通讯》更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划更多>>

(-)-Stepholodine induced enhancement of cardiac muscle contractions mediated by D_1 receptors: 《沈阳药科大学学报》2008年第S1期94-94,共1页ZHOU Shu-yuan1,2,3,LIU Zheng2,HU Hui-sheng1,2,3,SHI Zhen1,2,3,CHEN Long1,2,3(1.National Standard Laboratory of Pharmacology for Chinese Materia Medica,Nanjing 210029,China 2.Institute of traditional Chinese Medicine,Nanjing 210029,China 3.Research Center of Acupuncture and Pharmacology,Nanjing University of Chinese Medicine,Nanjing 210029,China); Objective To investigate the effect of(-)-Stepholidine(SPD)on enhancing D1 receptor mediated contraction of cardiac muscle in isolated rat heart and to examine whether SPD has a direct effect on the heart dopamine D1 ...; 关键词：(-)-Stepholidine D1 receptor L-TYPE CA2+ channel isolated working heart

小鼠睡眠生物解析系统与应用被引量：14: 《中国药理学通报》2008年第1期20-23,共4页邱梅红岳小芳徐昕红黄志力; 国家自然科学基金资助项目(No30570581,30625021);上海市浦江计划资助项目(No06PJ14008); 目的建立高度自动化小鼠睡眠生物解析系统,并考察作用于多巴胺D1/D2受体的左旋千金藤啶碱(L-stepholi-dine,SPD)对小鼠睡眠的影响。方法动物饲养在恒温、恒湿、隔音、静电屏蔽、12h/12h明暗光照环境下,利用Sleep-Sign软件,连续48h记录...; 关键词：睡眠脑电图肌电图 L-stepholidine 多巴胺受体拮抗剂

Effects of (-)-stepholidine on NMDA receptors:comparison with haloperidol and clozapine: 《Acta Pharmacologica Sinica》2007年第7期953-958,共6页Wei-hua GU Shen YANG Wei-xing SHI Xue-chu ZHEN Guo-zhang JIN; Projects supported by the Ministry of Science and Technology(№ 973-2003CB5154000);the National Natural Science Foundation of China(№ 30230130 and 30572168); Aim： To examine whether （-）-stepholidine （SPD） has a direct effect on the N- methyl-D-aspartic acid receptors （NMDAR） containing the NMDA receptor subunits NR2A or NR2B and to compare its effect with those of h...; 关键词：（-）-stepholidine HALOPERIDOL CLOZAPINE NMDA receptor calcium imaging neuro-leptics

I-Stepholidine increases the frequency of sEPSC via the activation of D_1 dopamine signaling pathway in rat prelimbic cortical neurons被引量：1: 《Acta Pharmacologica Sinica》2007年第5期627-633,共7页Ming GAO Chang-liang LIU Shen YANG Xue-chu ZHEN Guo-zhang JIN; the Ministry of Science and Technology(№ 973-2003CB5154000);the National Natural Science Foundation of China(№ 30271495,30230130); Aim： To investigate the effect of l-stepholidine （SPD） on the frequency of spontaneous excitatory postsynaptic currents （sEPSC） in the pyramidal cells between layers Ⅴ and Ⅵ in the prelimbic cortex （PL）. Meth...; 关键词：l-stepholidine prelimbic cortex whole-cellpatch clamp spontaneous excitatory postsynaptic currents dopamine receptor

Effects of(-)stepholidine in animal models for schizophrenia被引量：4: 《Acta Pharmacologica Sinica》2006年第9期1111-1118,共8页Bart A ELLENBROEK Xue-xiang ZHANG Guo-zhang JIN; Project supported by the National Basic Research Program 973 from Ministry of Science and Technology in China(№2003CB515401); Aim：（-）Stepholidine （SPD） is an active ingredient of the Chinese herb Stephania intermedia, which binds to the dopamine D1 and D2 like receptors. Biochemical, electrophysiological and behavioural experiments hav...; 关键词：acoustic startle response ANTIPSYCHOTICS APOMORPHINE dopamine D-1 receptor dopamine D-2 receptor MK801 paw test prepulse inhibition CLOZAPINE HALOPERIDOL

Towards Better Antipsychotic Drugs： an Update on 1 -Stepholidine: 《中国药理通讯》2005年第4期8-9,共2页Wei - Xing Shi Guo - Zhang Jin; 关键词：安定颅痛定延胡索千金藤啶碱神经类药物

左旋千金藤啶碱（1—stepholidine）新型药理作用的发现及意义: 《中国药理通讯》2002年第4期26-27,共2页金国章施卫星; 关键词：左旋千金藤啶碱 1-stepholidine 新型药理作用双羟基 D1激动-D2阻滞 1-THP 颅痛定受体阻滞剂

Relevance between striatal expression of Fos, proenkephalin mRNA, prodynorphin mRNA and rotation induced by l-stepholi- dine in 6-hydroxydopamine-lesioned rats: 《Acta Pharmacologica Sinica》2000年第10期24-31,共8页丁允闽唐放鸣俞蕾平傅雨张光毅金国章; Project supported by the National Natural Science Foundation of China, № 39670829; Key Laboratory of Neuroscience, Shanghai Institute of Physiology, Chinese Academy of Sciences.; AIM:To study that l-stepholidine(SPD) regulates the expression of proenkephalin (PENK) and prodynorphin (PDYN) mRNA and Fos in the striatum after rotational test in the 6-hydroxydopamine (6-OHDA)-lesioned rats. METHOD...; 关键词：STEPHOLIDINE corpus striatum 6-hy-droxydopamine in situ hybridization gene expression ENKEPHALINS DYNORPHINS fos genes

l-Stepholidine facilitates inhibition of mPFC DA receptors on subcortical NAc DA release被引量：1: 《Acta Pharmacologica Sinica》2000年第7期89-93,共5页朱子涛吴蔚然傅雨金国章; Project supported by the National Natural Science Foundation of China, № 39670829, 39770853.; tion of DA release in the NAc.To determine whether the D1 agonistic action of (-)-stepholidine (SPD) on the medial prefrontal cortex (mPFC) neuron is involved in the modulation of evoked subcortical dopamine (DA) rele...; 关键词：STEPHOLIDINE dopamine receptors dopamine MICRODIALYSIS AMPHETAMINE prefrontal cortex nucleus accumbens 6-HYDROXYDOPAMINE

Tetrahydroprotoberberines inhibit lipid peroxidation and scavenge hydroxyl free radicals被引量：4: 《Acta Pharmacologica Sinica》2000年第5期95-98,共4页金昔陆邵悦王铭洁陈丽娟金国章; Project supported by the National Natural Science Foundation of China, № 39870898.; AIM: To study the effects of tetrahydroprotoberberines (THPB) on rat liver and brain lipid peroxidation (LPO) and oxygen free radicals generation. METHODS: The malondialdehyde (MDA) levels in rat brain and liver ho-mo...; 关键词：STEPHOLIDINE lipid peroxidation MALONDIALDEHYDE MITOCHONDRIA free radicals

STEPHOLIDINE