云南高校图书馆联盟文献共享服务平台- APOMORPHINE

APOMORPHINE: 作品数：17被引量：25H指数：3; 导出分析报告; 相关领域：医药卫生更多>>; 相关作者：孙晓红张爱军乔善义郭继芬赵毅民更多>>; 相关机构：军事医学科学院武警总医院中国科学院上海生命科学研究院内蒙古医科大学更多>>; 相关期刊：《Asian Journal of Andrology》《兽类学报》《Acta Pharmacologica Sinica》《World Journal of Gastroenterology》更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划上海市科学技术委员会资助项目国家重点实验室开放基金更多>>

Why do‘OFF’periods still occur during continuous drug delivery in Parkinson’s disease?: 《Translational Neurodegeneration》2022年第1期280-293,共14页Silvia Rota Daniele Urso Daniel J.van Wamelen Valentina Leta Iro Boura Per Odin Alberto J.Espay Peter Jenner K.Ray Chaudhuri; Continuous drug delivery(CDD)is used in moderately advanced and late-stage Parkinson’s disease(PD)to control motor and non-motor fluctuations(‘OFF’periods).Transdermal rotigotine is indicated for early fluctuations...; 关键词：‘OFF’periods Continuous drug delivery Continuous dopaminergic stimulation Rotigotine patch Subcutaneous apomorphine infusion Levodopa-carbidopa intestinal gel

P2X4 receptor participates in autophagy regulation in Parkinson’s disease被引量：3: 《Neural Regeneration Research》2021年第12期2505-2511,共7页Xue Zhang Jing Wang Jin-Zhao Gao Xiao-Na Zhang Kai-Xin Dou Wan-Da Shi An-Mu Xie; This work was supported by the National Natural Science Foundation of China,Nos.81571225 and 81971192(both to AMX).; Dysfunctional autophagy often occurs during the development of neurodegenerative diseases,such as Parkinson’s disease,Huntington’s disease,and Alzheimer’s disease.The purinergic P2X4 receptor is an ATP-gated ion ch...; 关键词：6-HYDROXYDOPAMINE APOMORPHINE brain-derived neurotrophic factor dopaminergic neurons neuron degeneration P2X4R Parkinson’s disease TRKB AUTOPHAGY

Challenges and trends in apomorphine drug delivery systems for the treatment of Parkinson's disease被引量：1: 《Asian Journal of Pharmaceutical Sciences》2018年第6期507-517,共11页Nrupa Borkar Huiling Mu René Holm; The Lundbeck Foundation for the financial support(R108-A10772); Parkinson's disease(PD) is a chronic debilitating disease affecting approximately 1% of the population over the age of 60. The severity of PD is correlated to the degree of dopaminergic neuronal loss. Apomorphine has ...; 关键词：APOMORPHINE DRUG delivery Parkinson’s disease Alternative APOMORPHINE therapy NON-INVASIVE delivery EXCIPIENTS

Apomorphine effects on the hippocampus被引量：1: 《Neural Regeneration Research》2018年第12期2064-2066,共3页Luis Enrique Arroyo-García Antonio Rodríguez-Moreno Gonzalo Flores; supported by grants from the PRODEP,No.CA-BUAP-120;the CONACYT grant,No.252808(to GF);MINECO/FEDER grant,No.BFU2012-38208;the Junta de Andalucía,No.P11-CVI-7290(to ARM); Apomorphine is a non-specific dopamine receptor agonist that has been used in the treatment of some diseases and mental disorders. Its use has particularly well documented in Parkinson＇s disease（PD）. The dopaminerg...; 关键词：dopamine receptor APOMORPHINE HIPPOCAMPUS learning and memory PLASTICITY dendritic length oxidative stress Parkinson＇s disease

Degree of dopaminergic degeneration measured by ^(99m)Tc-TRODAT-1 SPECT/CT imaging被引量：3: 《Neural Regeneration Research》2018年第7期1281-1287,共7页Ling Lin Jing Ye Han Zhang Zhong-Fu Han Zhi-Hong Zheng; supported by the National Natural Science Foundation of China,No.81571250; To prevent and treat Parkinson＇s disease in its early stages,it is essential to be able to detect the degree of early dopaminergic neuron degeneration.Dopamine transporters（DAT） in the striatum regulate synaptic do...; 关键词：nerve regeneration Parkinson＇s disease 6-hydroxydopamine dopaminergic degeneration dopamine transporter ^99mTc-TRODAT-1 tyrosine hydroxylase substantia nigra striatum single-photon emission computed tomography apomorphine neurodegeneration neural regeneration

Continuous Apomorphine Infusion in Patients with Advanced Parkinson’s Disease with Varying Degrees of Functional Impairment: 《Journal of Behavioral and Brain Science》2016年第10期393-403,共12页Gabriel Salazar Marta Fragoso Jonatan Martí Noelia Martín Rosó Bernal; Introduction: Continuous apomorphine infusion (CAI) is effective in improving complications in advanced Parkinson’s disease (APD). The effectiveness and tolerance of CAI in patients with APD with varying degrees of f...; 关键词：Parkinson’s Disease Apo Morphine Continuous Dopaminergic Stimulation

多巴胺对长爪沙鼠贮食行为的影响: 《兽类学报》2015年第4期349-358,共10页杨慧娣王倩王德华; 农业虫害鼠害综合治理研究国家重点实验室资助项目(Chinese IPM1402);内蒙古医科大学博士启动基金项目(bsjj201306); 长爪沙鼠的贮食行为具有高低二型性。禁食诱导的贮食行为可能与中脑多巴胺(Dopamine,DA)系统有关,但尚乏证据。本文通过Fos标记相关脑区的活性,酪氨酸羟化酶(TH)标记DA神经元,以免疫组化方法观察对高贮食组长爪沙鼠腹腔注射DA拮抗剂halo...; 关键词：长爪沙鼠贮食行为多巴胺抑制剂haloperidol 多巴胺激动剂apomorphine

Involvement of CRH Receptors in the Neuroprotective Action of R-Apomorphine in the Striatal 6-OHDA Rat Model被引量：1: 《Neuroscience & Medicine》2013年第4期299-318,共20页Mustafa Varcin Eduard Bentea Steven Roosens Yvette Michotte Sophie Sarre; financial support of the Institute for the promotion of Innovation by Science and Technology in Flanders(IWT)(IWT420);National Fund for Scientific Research(FWO-Vlaanderen)(G.0071.05)and of the Research Council of the Vrije Universiteit Brussel;research grant from the IWT(IWT420).; The dopamine D1-D2 receptor agonist, R-apomorphine, has been shown to be neuroprotective in different models of Parkinson’s disease. Different mechanisms of action for this effect have been proposed, but not verified...; 关键词：APOMORPHINE Gene Expression Inflammation Neuroprotection Parkinson’s Disease Striatal 6-Hydroxydopamine Rat Model

Reduced normogastric electrical activity associated with emesis:A telemetric study in ferrets: 《World Journal of Gastroenterology》2009年第48期6034-6043,共10页Nathalie Percie du Sert Kit M Chu Man K Wai John A Rudd Paul LR Andrews; Supported by A PhD studentship from Merck Research Laboratories (to Percie du Sert N); AIM： To characterize the gastric myoelectric activity （GMA） and intra-abdominal pressure changes induced by emetic stimuli （apomorphine and cisplatin） in the ferret. METHODS： GMA and intra-abdominal pressure wer...; 关键词：EMESIS NAUSEA Stomach FERRET Cisplatin APOMORPHINE ELECTROMYOGRAPHY

Effects of(-)stepholidine in animal models for schizophrenia被引量：4: 《Acta Pharmacologica Sinica》2006年第9期1111-1118,共8页Bart A ELLENBROEK Xue-xiang ZHANG Guo-zhang JIN; Project supported by the National Basic Research Program 973 from Ministry of Science and Technology in China(№2003CB515401); Aim：（-）Stepholidine （SPD） is an active ingredient of the Chinese herb Stephania intermedia, which binds to the dopamine D1 and D2 like receptors. Biochemical, electrophysiological and behavioural experiments hav...; 关键词：acoustic startle response ANTIPSYCHOTICS APOMORPHINE dopamine D-1 receptor dopamine D-2 receptor MK801 paw test prepulse inhibition CLOZAPINE HALOPERIDOL

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