Research review Neuropeptides and traumatic brain injury  

作　　者：王国良 朱诚 

机构地区：[1]Department of Neurosurgery,Changzheng Hospital,Second Military Medical University,Shanghai 200003

出　　处：《Journal of Medical Colleges of PLA(China)》1992年第1期84-89,共6页中国人民解放军军医大学学报（英文版）

摘　　要：It has been proved that endogenous opioids play an important pathophysiological role inthe lesions secondary to central nervous system trauma.Opiate antagonists and opioid antisera havebeen found to improve the outcome of experimental brain injury,Thyrotropin-releasing hormone(TRH),which appears to act in part as a functional antagonist of opioid system,has also beenproved to be effective in the treatment of experimental brain injury.The developments of these as-pects in our laboratory are reviewed.It has been proved that endogenous opioids play an important pathophysiological role in the lesions secondary to central nervous system trauma.Opiate antagonists and opioid antisera have been found to improve the outcome of experimental brain injury,Thyrotropin-releasing hormone (TRH),which appears to act in part as a functional antagonist of opioid system,has also been proved to be effective in the treatment of experimental brain injury.The developments of these as- pects in our laboratory are reviewed.

关 键 词：beta-endorphins DYNORPHINS thyrotropin-releasing HORMONE brain injuries 

分 类 号：R[医药卫生]