Radiosensitivity of β-elemene on rabbit VX2 renal transplant carcinoma model  

作　　者：佘军军 王子明 张鹏鸽 甘为民 程伟 种铁 车向明 

机构地区：[1]Department of Urology, the Second Affiliated Hospital,Medical School of Xi'an Jiaotong University [2]Department of Mathematics,Xidian University [3]Department of Gastrointestinal Surgery,the First Affiliated Hospital,Medical School of Xi'an Jiaotong University

出　　处：《Journal of Pharmaceutical Analysis》2007年第2期217-219,234,共4页药物分析学报（英文版）

基　　金：This work was supported by the National Natural Science Foundation of China (No30371831)

摘　　要：Objective To investigate the effects of low dosage of β-elemene on the radiosensitivity of rabbit VX2 renal transplant carcinoma model. Methods We took the rabbit VX2 renal transplant carcinoma as the model. Experimental rabbits were divided into three groups: the control group, the radiation group, and the radiation +β-elemene (radiosensitivity) group. The change of tumor was observed by Spiral CT and B ultrasound to compare its regrowth period. The tumor was measured by light microscopy and electron microscopy. Results The tumor in radiosensitivity group was restrained obviously and the sensitization enhancement ratio (SER) of β-elemene was 1.89. Different apoptosis was observed under transmission electron microscopy. Conclusion Low dosage β-elemene can enhance the radiosensitivity of rabbit VX2 renal transplant carcinoma model and induce the apoptosis of tumor cells, but the mechanism needs further study. It promotes apoptosis in mechanisms in vitro.Objective To investigate the effects of low dosage of β-elemene on the radiosensitivity of rabbit VX2 renal transplant carcinoma model. Methods We took the rabbit VX2 renal transplant carcinoma as the model. Experimental rabbits were divided into three groups: the control group, the radiation group, and the radiation +β-elemene (radiosensitivity) group. The change of tumor was observed by Spiral CT and B ultrasound to compare its regrowth period. The tumor was measured by light microscopy and electron microscopy. Results The tumor in radiosensitivity group was restrained obviously and the sensitization enhancement ratio (SER) of β-elemene was 1.89. Different apoptosis was observed under transmission electron microscopy. Conclusion Low dosage β-elemene can enhance the radiosensitivity of rabbit VX2 renal transplant carcinoma model and induce the apoptosis of tumor cells, but the mechanism needs further study. It promotes apoptosis in mechanisms in vitro.

关 键 词：Β-ELEMENE rabbit VX2 carcinoma model RADIOSENSITIZATION apoptosis 

分 类 号：R737.11[医药卫生—肿瘤]