市售炉甘石的化学成分及抑菌活性研究  

Study on chemical composition and antibacterial activity of Calamine for sale

作　　者：张杰红[1] 刘友平[1] 施学骄[1] 彭月[1] 银铃[1] 

机构地区：[1]成都中医药大学药学院中药材标准化教育部重点实验室中药资源系统研究与开发利用省部共建国家重点实验室培育基地,四川成都610075

出　　处：《中药与临床》2011年第6期16-18,共3页Pharmacy and Clinics of Chinese Materia Medica

基　　金：2011年中医药行业科研专项(201007011-10)

摘　　要：目的:对市售炉甘石的成分及抑菌活性进行比较。方法:采用滴定法和X射线衍射(XRD)对炉甘石进行成分分析,采用差热分析对炉甘石的稳定性进行分析,以盐酸四环素为对照,测定市售炉甘石的抑菌活性。结果:只有1批炉甘石主要成分为碱式碳酸锌[Zn5(CO3)2(OH)6],符合药典标准,其它3批市售炉甘石以碳酸钙(CaCO3)为主要成分,不含或含少量应有的碳酸锌(ZnCO3);差热分析结果表明以Zn5(CO3)2(OH)6为主成分的炉甘石和以CaCO3为主成分的样品发生相变的温度不同;抑菌活性实验表明以Zn5(CO3)2(OH)6为主要成分的炉甘石具有抑菌作用,而以CaCO3为主要成分的样品无抑菌作用。结论:市售炉甘石存在严重的质量问题,有必要加强对该类矿物药材的质量监管,以保证安全、有效、合理用药。Objective:To compare the component and antibacterial activity of Calamine for sale.Method:Using titration and X-ray diffraction(XRD) to analyze component of Calamine;study the thermal stability of Calamine by using differential thermal analysis(DTA);using tetracycline hydrochloride as a reference substance to measure the antibacterial activity of Calamine for sale.Result:Only one batch of Calamine was in line with pharmacopoeia standards and the main component was Zn5(CO3)2(OH)6;but the other three batches of Calamine were not in line with pharmacopoeia standards and the main component was CaCO3,not or a small amount of ZnCO3;results of differential thermal analysis showed the different phase transition temperature between the Calamine with Zn5(CO3)2(OH)6 and the sample with CaCO3;the Calamine with Zn5(CO3)2(OH)6 had antibacterial activity,but the sample with CaCO3 did not.Conclusion:The Calamine for sale has seriously quality problems.It needs to strengthen the supervision to ensure safe,effective and rational use of drugs.

关 键 词：市售 炉甘石 化学成分 抑菌活性 

分 类 号：R282.76[医药卫生—中药学]