生物法在制备抗癌药物紫杉醇中的应用  

Application of biological method in the producing taxol

作　　者：申红蕾[1] 俞国伟[1] 凌金龙[1] 朱勍[1] 

机构地区：[1]浙江工业大学生物与环境工程学院,浙江杭州310014

出　　处：《发酵科技通讯》2013年第4期41-44,53,共5页Bulletin of Fermentation Science and Technology

摘　　要：紫杉醇是一种新型高效的抗癌药物,传统的从植物中直接提取法已不能满足人们对紫杉醇的需求。本文综述了生物法在紫杉醇生产中的应用,重点介绍了微生物直接发酵法、酶-化学半合成法制备紫杉醇的研究。Taxol is a novel and efficient drug with excellent activity against a range of cancers,the traditional method for producing taxol is extraction from plants directly, but the low production can not meet the needs of the people now. This article reviews the application of biological technique in taxol production, Especially fermentation of paclitaxel-producing fungi and enzymes-chemical prepared paclitaxel, which are the two most promising approaches for taxol.

关 键 词：紫杉醇 微生物发酵 化学-酶法半合成 脂肪水解酶 环氧化物水解酶 

分 类 号：S79[农业科学—林木遗传育种] S18[农业科学—林学]