动脉粥样硬化分子遗传学研究进展与转化医学应用  

作　　者：凃欣[1,2] 王擎[1,2] 

机构地区：[1]分子生物物理教育部重点实验室华中科技大学生命科学与技术学院 [2]华中科技大学人类基因组研究中心,武汉430074

出　　处：《中国医学前沿杂志（电子版）》2011年第5期16-20,共5页Chinese Journal of the Frontiers of Medical Science(Electronic Version)

摘　　要：动脉粥样硬化,是一类由遗传、环境因素及其之间的相互作用引起的复杂性疾病,主要包括冠心病、心肌梗死、脑卒中等。自2007年,已有22项全基因组关联分析研究发现了超过40个动脉粥样硬化相关基因,这极大地推动了动脉粥样硬化的分子遗传学研究进展,并为未来的转化医学研究和临床实践提供了基础。Artery atherosclerosis is a kind of complex disease caused by genetic factors, environmental factors and their interaction; it includes coronary artery disease, myocardial infarction and stroke. Since the year of 2007, there are 22 genome-wide association studies identifying over 40 artery atherosclerosis related susceptibility genes; it promotes the molecular genetics of artery atherosclerosis to develop rapidly and also indicate that a new era of translational medicine is coming. Based on the genome-wide association studies, gene tests might be useful for prediction of artery atherosclerosis, and how to practice in clinics should be studies in future.

关 键 词：动脉粥样硬化 全基因组关联分析 转化医学 基因检测 

分 类 号：R543.5[医药卫生—心血管疾病]