The protective effects of verapamil and SOD on ESW-induced kidney damage  

作　　者：林宗明 

机构地区：[1]Dept Urol, Zhongshan Hosp, Fudan Univ, Shanghai 200032

出　　处：《外科研究与新技术》2003年第2期113-113,共1页Surgical Research and New Technique

摘　　要：Objective To investigate the protective effects of calcium channel blockade and oxygen free radical catalase on ESWL-nduced kidney damage. Methods 120 female uninephrectomized rat models were randomizedly divided into six groups. After verapamil and (or) SOD injection, the kidneys were shocked 1 000 times at 14 kV by ESW. Then ET level in kidney tissue,levels of NAG,MDA,ET in urine, variation of creatinine clearance (Ccr) and the kidney histopathological changes were evaluated. Results The variation of NAG and MDA level in urine and the Ccr in the therapeutic groups were significantly lower and the histopathological changes were also much slight than those in the control group. There was no significant difference of the biochemical and pathological changes when the dose of SOD increased from 20 thousang units to June 2003 Vol12 No2 40 thousand units per kg body weight. If verapamil was used, the levels of ET in kidney tissue and in urine both decreased. Combined use of SOD and verapamil can induceObjective To investigate the protective effects of calcium channel blockade and oxygen free radical catalase on ESWL-nduced kidney damage. Methods 120 female uninephrectomized rat models were randomizedly divided into six groups. After verapamil and (or) SOD injection, the kidneys were shocked 1 000 times at 14 kV by ESW. Then ET level in kidney tissue,levels of NAG,MDA,ET in urine, variation of creatinine clearance (Ccr) and the kidney histopathological changes were evaluated. Results The variation of NAG and MDA level in urine and the Ccr in the therapeutic groups were significantly lower and the histopathological changes were also much slight than those in the control group. There was no significant difference of the biochemical and pathological changes when the dose of SOD increased from 20 thousang units to June 2003 Vol12 No2 40 thousand units per kg body weight. If verapamil was used, the levels of ET in kidney tissue and in urine both decreased. Combined use of SOD and verapamil can induce better protective effects. Conclusion Calcium channel blokade could decrease not only the degree of lipid overoxidation, but also the level of ET-Relieve, so it can induce a marked protective effect on ESW-induced kidney damage and the effect could be much enhanced if combined with SOD. 12 refs.

关 键 词：VERAPAMIL protective URINE CREATININE CATALASE CLEARANCE BIOCHEMICAL thousand slight body 

分 类 号：R692[医药卫生—泌尿科学]