Endoscopic imaging:How far are we from real-time histology?  

作　　者：Richa Shukla Wasif M Abidi Rebecca Richards-Kortum Sharmila Anandasabapathy 

机构地区：[1]Department of Medicine,Mount Sinai School of Medicine [2]Department of Bioengineering,Rice University [3]Division of Gastroenterology,Mount Sinai School of Medicine

出　　处：《World Journal of Gastrointestinal Endoscopy》2011年第10期183-194,共12页世界胃肠内镜杂志（英文版）（电子版）

摘　　要：Currently,in gastrointestinal endoscopy there is increasing interest in high resolution endoscopic technologies that can complement high-definition white light endoscopy by providing real-time subcellular imaging of the epithelial surface.These 'optical biopsy' technologies offer the potential to improve diagnostic accuracy and yield,while facilitating real-time decision-making.Although many endoscopic techniques have preliminarily shown high accuracy rates,these technologies are still evolving.This review will provide an overview of the most promising high-resolution imaging technologies,including high resolution microendoscopy,optical coherence tomography,endocytoscopy and confocal laser endoscopy.This review will also discuss the application and current limitations of these technologies for the early detection of neoplasia in Barrett's esophagus,ulcerative colitis and colorectal cancer.Currently, in gastrointestinal endoscopy there is increasing interest in high resolution endoscopic technologies that can complement high-definition white light endoscopy by providing real-time subcellular imaging of the epithelial surface. These ‘optical biopsy’ technologies offer the potential to improve diagnostic accuracy and yield, while facilitating real-time decision-making. Although many endoscopic techniques have preliminarily shown high accuracy rates, these technologies are still evolving. This review will provide an overview of the most promising high-resolution imaging technologies, including high resolution microendoscopy, optical coherence tomography, endocytoscopy and confocal laser endoscopy. This review will also discuss the application and current limitations of these technologies for the early detection of neoplasia in Barrett’s esophagus, ulcerative colitis and colorectal cancer.

关 键 词：MICROENDOSCOPY Confocal laser endoscopy ENDOCYTOSCOPY High-resolution Optical coherence tomography Barrett’s ESOPHAGUS ULCERATIVE COLITIS Colon cancer 

分 类 号：TP391.41[自动化与计算机技术—计算机应用技术]