Osteoclastic and pleomorphic giant cell tumors of the pancreas:A review of clinical,endoscopic,and pathologic features  

作　　者：Jill C Moore Joel S Bentz Kristen Hilden Douglas G Adler 

机构地区：[1]Division of Gastroenterology and Hepatology,Department of Internal Medicine,University of Utah School of Medicine,Salt Lake City,UT 84132,United States [2]Department of Pathology,University of Utah School of Medicine,Salt Lake City,UT 84132,United States

出　　处：《World Journal of Gastrointestinal Endoscopy》2010年第1期15-19,共5页世界胃肠内镜杂志（英文版）（电子版）

摘　　要：Giant cell tumors of the pancreas come in three varieties-osteoclastic,pleomorphic,and mixed histology.These tumors have distinctive endoscopic,clinical,and cytological features.Giant cell tumors have a controversial histogenesis,with some authors favoring an epithelial origin and others favoring a mesenchymal origin.The true origin of these lesions remains unclear at this time.These are also very rare tumors but proper identification and differentiation from more common pancreatic adenocarcinoma is important.The risk factors of these tumors and the prognosis may be different from those associated with standard pancreatic adenocarcinoma.Recognition of these differences can significantly affect patient care.These lesions have a unique appearance when imaged with endoscopic ultrasound(EUS),and these lesions can be diagnosed via EUS guided Fine Needle Aspiration(FNA).This manuscript will review the endoscopic,clinical,and pathologic features of these tumors.Giant cell tumors of the pancreas come in three varieties-osteoclastic, pleomorphic, and mixed histology. These tumors have distinctive endoscopic, clinical, and cytological features. Giant cell tumors have a controversial histogenesis, with some authors favoring an epithelial origin and others favoring a mesenchymal origin. The true origin of these lesions remains unclear at this time. These are also very rare tumors but proper identification and differentiation from more common pancreatic adenocarcinoma is important. The risk factors of these tumors and the prognosis may be different from those associated with standard pancreatic adenocarcinoma. Recognition of these differences can significantly affect patient care. These lesions have a unique appearance when imaged with endoscopic ultrasound (EUS), and these lesions can be diagnosed via EUS guided Fine Needle Aspiration (FNA). This manuscript will review the endoscopic, clinical, and pathologic features of these tumors.

关 键 词：Osteoclastic PLEOMORPHIC GIANT cell tumor PANCREAS ENDOSCOPIC PATHOLOGIC CLINICAL Feature 

分 类 号：R735.9[医药卫生—肿瘤]