Evaluating long-term attachment of two different endoclips in the human gastrointestinal tract  

作　　者：Hendrik Albert Maurits Swellengrebel Cornelia Adriana Maria Marijnen Andrew Vincent Annemieke Cats 

机构地区：[1]Department of Gastroenterology and Hepatology,the Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital,Plesmanlaan 121,Amsterdam 1066CX,The Netherlands [2]Department of Clinical Oncology,Leiden University Medical Centre,Post box 9600,Leiden 2300 RC,The Netherlands [3]Department of Radiation Oncology,the Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital,Plesmanlaan 121,Amsterdam 1066 CX,The Netherlands [4]Department of Biostatistics,the Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital,Plesmanlaan 121,Amsterdam 1066CX,The Netherlands

出　　处：《World Journal of Gastrointestinal Endoscopy》2010年第10期344-348,共5页世界胃肠内镜杂志（英文版）（电子版）

摘　　要：AIM:To evaluate the long-term attachment of two types of endoclips in the human gastrointestinal tract. METHODS:In this prospective observational study,endoclips were placed and followed-up during endoscopies or using fluoroscopic images as part of a pro s pective feasibility study evaluating external beam radiotherapy (EBRT,wk 1-3) followed by high dose rate brachytherapy (HDRBT with an endoluminal app licator once a week for 3 wk,wk 9-11) in medically inoperablerectal cancer patients. Initially,the type and number of endoclips were chosenrandomly and later refined to 1 Resolution clip (Microvasive) proximal and 2 Quickclips (Olympus) distal to the tumor. Nine consecutive patients from between September 2007 and August 2008 were analyzed. Retention rates were evaluated over three different observational periods [period 1:pre-HDRBT (wk-2-8),period 2:during HD RBT (wk 9-11) and period 3:post-HDRBT (wk 1216)]. RESULTS:In this study,a total of 44 clips were placed during endoscopy,either at the beginning or at the end of period 1. The Resolution clip had a higher overall retention rate than the Quickclip (P = 0.01). After a median period of 81 d after placement (in period 1),longterm retention rates for the Resolution clip and Quickclip clip were 67% and 35% respectively. CONCLUSION:The Resolution clip has a high retention rate and is useful in situations where long-term attachment to the human gastrointestinal mucosa is warranted.AIM: To evaluate the long-term attachment of two types of endoclips in the human gastrointestinal tract.METHODS: In this prospective observational study, endoclips were placed and followed-up during endoscopies or using fluoroscopic images as part of a prospective feasibility study evaluating external beam radiotherapy (EBRT, wk 1-3) followed by high dose rate brachytherapy (HDRBT with an endoluminal applicator once a week for 3 wk, wk 9-11) in medically inoperable rectal cancer patients. Initially, the type and number of endoclips were chosen randomly and later refined to 1 Resolution? clip (Microvasive) proximal and 2 Quickclips? (Olympus) distal to the tumor. Nine consecutive patients, included between September 2007 and August 2008 were analyzed. Retention rates were evaluated over three different observational periods [period 1: pre-HDRBT (wk -2-8), period 2: during HDRBT (wk 9-11) and period 3: post-HDRBT (wk 12-16)].RESULTS: In this study, a total of 44 clips were placed during endoscopy, either at the beginning or at the end of period 1. The Resolution clip had a higher overall retention rate than the Quickclip (P = 0.01). After a median period of 81 d after placement (in period 1), long-term retention rates for the Resolution clip and Quickclip clip were 67% and 35% respectively.CONCLUSION: The Resolution clip has a high retention rate and is useful in situations where long-term attachment to the human gastrointestinal mucosa is warranted.

关 键 词：ENDOCLIP RADIOTHERAPY RETENTION rate Cancer DELINEATION 

分 类 号：R735[医药卫生—肿瘤]