Bone lesions in recurrent glucagonoma: A case report and review of literature  

作　　者：Cristian Ghetie Daniel Cornfeld Vassilios S Ramfidis Kostas N Syrigos Muhammad W Saif 

机构地区：[1]Danbury Hospital, Danbury, CT 06810, United States [2]Department of Diagnostic Radiology, Yale School of Medicine, New Haven, CT 06510, United States [3]Third Department of Medicine, Sotiria General Hospital, Athens Medical School, Athens 11527, Greece [4]Section of Medical Oncology, Yale School of Medicine, New Haven, CT 06510, United States [5]Division of Hematology and Oncology, Department of Medicine, Columbia University, NY 10032, United States

出　　处：《World Journal of Gastrointestinal Oncology》2012年第6期152-155,共4页世界胃肠肿瘤学杂志（英文版）（电子版）

摘　　要： Glucagonomas are rare neuroendocrine tumors that arise from cells of the pancreatic islets. Most of them are malignant and usually present as metastatic disease. Sites most commonly involved in metastases are the liver and regional lymph nodes. Bone metastases are rare events and only a few cases have been reported in the literature. We present the case of a 53-year-old male with a medical history of recurrent non-functioning glucagonoma. He presented 17 years after the initial diagnosis with new blastic bone lesions involving the T1 vertebra and the sacrum. Diagnostic steps and medical management in metastatic glucagonoma are also reviewed.Glucagonomas are rare neuroendocrine tumors that arise from α cells of the pancreatic islets. Most of them are malignant and usually present as metastatic disease. Sites most commonly involved in metastases are the liver and regional lymph nodes. Bone metastases are rare events and only a few cases have been reported in the literature. We present the case of a 53-year-old male with a medical history of recurrent non-functioning glucagonoma. He presented 17 years after the initial diagnosis with new blastic bone lesions involving the T1 vertebra and the sacrum. Diagnostic steps and medical management in metastatic glucagonoma are also reviewed.

关 键 词：GLUCAGONOMA BONE METASTASES BLASTIC LESION Octreoscan 

分 类 号：R738[医药卫生—肿瘤]