Extensive multiarterial resection attending total duodenopancreatectomy and adrenalectomy for MEN-1-associated neuroendocrine carcinomas  

作　　者：Vyacheslav Ivanovich Egorov Alexander Felixovich Kharazov Alla Ivanovna Pavlovskaya Roman Valeryevich Petrov Natalia Sergeevna Starostina Eugeny Valerievich Kondratiev Ekaterina Mikhailovna Filippova 

机构地区：[1]Department of Hepatopancreatobiliary Surgery,Vishnevsky Institute of Surgery,117997 Moscow,Russia [2]Department of Vascular Surgery,Vishnevsky Institute of Surgery,117997 Moscow,Russia [3]Department of Pathology,Blokhin Cancer Research Centre Moscow,117997 Moscow,Russia [4]Department of Radiology,Vishnevsky Institute of Surgery,117997 Moscow,Russia [5]Department of Pathology,Vishnevsky Institute of Surgery,117997 Moscow,Russia

出　　处：《World Journal of Gastrointestinal Surgery》2012年第10期238-245,共8页世界胃肠外科杂志（英文版）（电子版）

摘　　要：Pancreatic neuroendocrine tumors(PNTs) are relatively uncommon although these neoplasms have been noted to grow in occurrence in recent decades.Surgical removal of locally advanced PNTs involving major vessels and adjacent organs is warranted by reason of an appreciably more favorable prognosis as compared to exocrine pancreas cancer.We are reporting a case of successful multi-organ resection combined with a wide excision of the superior mesenteric,common,proper,left and right hepatic arteries(in the presence of the hepatomesenteric trunk variant of aberrant arterial anatomy) for multifocal PNTs in the setting of multiple neuroendocrine neoplasia type 1 syndrome.The procedure resulted in pain abolition,a significant improvement in the patient's life quality and allowed her to return to work.Follow-up computed tomography at 15 mo post-surgery showed no evidence of disease recurrence.Pancreatic neuroendocrine tumors (PNTs) are relatively uncommon although these neoplasms have been noted to grow in occurrence in recent decades. Surgical removal of locally advanced PNTs involving major vessels and adjacent organs is warranted by reason of an appreciably more favorable prognosis as compared to exocrine pancreas cancer. We are reporting a case of successful multi-organ resection combined with a wide excision of the superior mesenteric, common, proper, left and right hepatic arteries (in the presence of the hepatomesenteric trunk variant of aberrant arterial anatomy) for multifocal PNTs in the setting of multiple neuroendocrine neoplasia type 1 syndrome. The procedure resulted in pain abolition, a significant improvement in the patient’s life quality and allowed her to return to work. Follow-up computed tomography at 15 mo post-surgery showed no evidence of disease recurrence.

关 键 词：TOTAL DUODENOPANCREATECTOMY Pancreatic NEUROENDOCRINE TUMORS ISLET cell TUMORS NEUROENDOCRINE carcinoma Multiple endocrine neoplasia type 1 syndrome 

分 类 号：R735.9[医药卫生—肿瘤]