Low-grade inflammation plays a pivotal role in gastrointestinal dysfunction in irritable bowel syndrome  

作　　者：Hirotada Akiho Eikichi Ihara Kazuhiko Nakamura 

机构地区：[1]Department of Medicine and Bioregulatory Science,Graduate School of Medical Sciences,Kyushu University

出　　处：《World Journal of Gastrointestinal Pathophysiology》2010年第3期97-105,共9页世界胃肠病理生理学杂志（英文版）（电子版）

摘　　要：The pathogenesis of irritable bowel syndrome (IBS) is considered to be multifactorial and includes psychosocial factors, visceral hypersensitivity, infection, microbiota and immune activation. It is becoming increasingly clear that low-grade inflammation is present in IBS patients and a number of biomarkers have emerged. This review describes the evidence for low-grade inflammation in IBS and explores its mechanism with particular focus on gastrointestinal motor dysfunction. Understanding of the immunological basis of the altered gastrointestinal motor function in IBS may lead to new therapeutic stra- tegies for IBS.The pathogenesis of irritable bowel syndrome (IBS) is considered to be multifactorial and includes psychosocial factors, visceral hypersensitivity, infection, microbiota and immune activation. It is becoming increasingly clear that low-grade inflammation is present in IBS patients and a number of biomarkers have emerged. This review describes the evidence for low-grade inflammation in IBS and explores its mechanism with particular focus on gastrointestinal motor dysfunction. Understanding of the immunological basis of the altered gastrointestinal motor function in IBS may lead to new therapeutic strategies for IBS.

关 键 词：IRRITABLE BOWEL syndrome SEROTONIN Enteri-tis Gastrointestinal MOTILITY 

分 类 号：R574[医药卫生—消化系统]