Primary prevention of bleeding from esophageal varices in patients with liver cirrhosis  

作　　者：Christos Triantos Maria Kalafateli 

机构地区：[1]Department of Gastroenterology,University Hospital of Patras

出　　处：《World Journal of Hepatology》2014年第6期363-369,共7页世界肝病学杂志（英文版）（电子版）

摘　　要：Variceal bleeding is a life threatening situation with mortality rates of at least 20%. Prophylactic treatment with non-selective beta blockers(NSBBs) is recommended for patients with small varices that have not bled but with increased risk for bleeding. The recommended treatment strategies on primary prevention of variceal bleeding in patients with medium and largesized varices are NSBBs or endoscopic band ligation. Nitrates, shunt surgery and sclerotherapy are not recommended in this setting. In this review, the most recent data on prevention of esophageal variceal bleeding are presented. Available data derived from randomized-controlled trials suggest both treatment strategies, and according to Baveno V consensus in portal hypertension "the choice of treatment should be based on local resources and expertise, patient preference and characteristics, side-effects and contra-indications".Variceal bleeding is a life threatening situation with mortality rates of at least 20%. Prophylactic treatment with non-selective beta blockers(NSBBs) is recommended for patients with small varices that have not bled but with increased risk for bleeding. The recommended treatment strategies on primary prevention of variceal bleeding in patients with medium and largesized varices are NSBBs or endoscopic band ligation. Nitrates, shunt surgery and sclerotherapy are not recommended in this setting. In this review, the most recent data on prevention of esophageal variceal bleeding are presented. Available data derived from randomized-controlled trials suggest both treatment strategies, and according to Baveno V consensus in portal hypertension 'the choice of treatment should be based on local resources and expertise, patient preference and characteristics, side-effects and contra-indications'.

关 键 词：CIRRHOSIS Portal hypertension Esophageal varices Primary prevention Β-BLOCKERS Endoscopic band ligation 

分 类 号：R57[医药卫生—消化系统]