Glioblastoma stem cells:Molecular characteristics and therapeutic implications  

作　　者：Nermin Sumru Bayin Aram Sandaldjian Modrek Dimitris George Placantonakis 

机构地区：[1]Department of Neurosurgery,New York University School of Medicine [2]Stem Cell Biology Training Program,New York University School of Medicine [3]Medical Scientist Training Program,New York University School of Medicine [4]Kimmel Center for Stem Cell Biology,New York University School of Medicine [5]Brain Tumor Center,New York University School of Medicine

出　　处：《World Journal of Stem Cells》2014年第2期230-238,共9页世界干细胞杂志（英文版）（电子版）

基　　金：Supported by Bayin NS received support from NYSTEM Institutional training grant,No.CO26880;support from the Medical Scientist Training Program at NYU School of Medicine;support from NIH/NINDS 1R21NS087241-01,NIH/NCI 2P30CA016087-33,NIH/NCATS UL1 TR000038;NYU Cancer Institute;NYU Clinical and Translational Science Institute

摘　　要：Glioblastoma Multiforme(GBM)is a grade IV astrocytoma,with a median survival of 14.6 mo.Within GBM,stem-like cells,namely glioblastoma stem cells(GSCs),have the ability to self-renew,differentiate into distinct lineages within the tumor and initiate tumor xenografts in immunocompromised animal models.More importantly,GSCs utilize cell-autonomous and tumor microenvironment-mediated mechanisms to overcome current therapeutic approaches.They are,therefore,very important therapeutic targets.Although the functional criteria defining GSCs are well defined,their molecular characteristics,the mechanisms whereby they establish the cellular hierarchy within tumors,and their contribution to tumor heterogeneity are not well understood.This review is aimed at summarizing current findings about GSCs and their therapeutic importance from a molecular and cellular point of view.A better characterization of GSCs is crucial for designing effective GSCtargeted therapies.Glioblastoma Multiforme(GBM)is a grade IV astrocytoma,with a median survival of 14.6 mo.Within GBM,stem-like cells,namely glioblastoma stem cells(GSCs),have the ability to self-renew,differentiate into distinct lineages within the tumor and initiate tumor xenografts in immunocompromised animal models.More importantly,GSCs utilize cell-autonomous and tumor microenvironment-mediated mechanisms to overcome current therapeutic approaches.They are,therefore,very important therapeutic targets.Although the functional criteria defining GSCs are well defined,their molecular characteristics,the mechanisms whereby they establish the cellular hierarchy within tumors,and their contribution to tumor heterogeneity are not well understood.This review is aimed at summarizing current findings about GSCs and their therapeutic importance from a molecular and cellular point of view.A better characterization of GSCs is crucial for designing effective GSCtargeted therapies.

关 键 词：GLIOBLASTOMA GLIOBLASTOMA stem cells Selfrenewal DIFFERENTIATION Molecular MARKERS Therapy resistance 

分 类 号：R457.7[医药卫生—治疗学]