Heart failure in subjects with chronic kidney disease:Best management practices  

作　　者：Farhan Aslam Attiya Haque Javeria Haque Jacob Joseph 

机构地区：[1]Department of Medicine,Brigham and Women's Hospital [2]Department of Medicine,Veterans Affairs Boston Healthcare System [3]Department of Medicine,Boston University School of Medicine

出　　处：《World Journal of Cardiology》2010年第5期112-117,共6页世界心脏病学杂志（英文版）（电子版）

摘　　要：Renal dysfunction is common in patients with heart failure(HF) and can complicate HF therapy.Treating patients with HF and kidney disease is difficult and requires careful assessment,monitoring and balancing of risk between potential benefits of treatment and adverse impact on renal function.In this review,we address the pathophysiological contexts and management options in this adversarial relation between the heart and the kidney,which exists in a substantial proportion of HF patients.Angiotensin converting enzyme inhibitors and β-blockers are associated with similar reductions in mortality in patients with and without renal insufficiency but usually are less often prescribed in patients with renal insufficiency.Careful monitoring of side effects and renal function should be done in all patients with renal insufficiency and prompt measures should be adopted to prevent further complications.Renal dysfunction is common in patients with heart failure (HF) and can complicate HF therapy. Treating patients with HF and kidney disease is difficult and requires careful assessment, monitoring and balancing of risk between potential benefits of treatment and adverse impact on renal function. In this review, we address the pathophysiological contexts and management options in this adversarial relation between the heart and the kidney, which exists in a substantial proportion of HF patients. Angiotensin converting enzyme inhibitors and β-blockers are associated with similar reductions in mortality in patients with and without renal insufficiency but usually are less often prescribed in patients with renal insufficiency. Careful monitoring of side effects and renal function should be done in all patients with renal insufficiency and prompt measures should be adopted to prevent further complications.

关 键 词：Kidney disease Heart failure ANGIOTENSIN SYMPATHETIC nervous system Left VENTRICULAR HYPERTROPHY 

分 类 号：R541.6[医药卫生—心血管疾病] R692[医药卫生—内科学]