Alterations in cell adhesion proteins and cardiomyopathy  

作　　者：Jifen Li 

机构地区：[1]Center for Translational Medicine, Department of Medicine, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107, United States

出　　处：《World Journal of Cardiology》2014年第5期304-313,共10页世界心脏病学杂志（英文版）（电子版）

基　　金：Supported by American Heart Association Scientist Development Grant,No.N2080068;W.W.Smith Charitable Trust Foundation Grant(H1204)

摘　　要：Cell adhesive junction is specialized intercellular struc-ture composed of cell adhesion proteins. They are essential to connect adjacent heart muscle cell and make heart contraction effectively and properly. Clini-cal and genetic studies have revealed close relationship between cell adhesive proteins and the occurrence of various cardiomyopathies. Here we will review recent development on the disease phenotype, potential cel-lular and molecular mechanism related to cell adhesion molecules, with particular disease pathogenesis learned from genetic manipulated murine models.Cell adhesive junction is specialized intercellular struc-ture composed of cell adhesion proteins. They are essential to connect adjacent heart muscle cell and make heart contraction effectively and properly. Clini-cal and genetic studies have revealed close relationship between cell adhesive proteins and the occurrence of various cardiomyopathies. Here we will review recent development on the disease phenotype, potential cel-lular and molecular mechanism related to cell adhesion molecules, with particular disease pathogenesis learned from genetic manipulated murine models.

关 键 词：CARDIOMYOPATHY Adherens junction DESMOSOME INTERCALATED DISC ARRHYTHMIA 

分 类 号：R542.2[医药卫生—心血管疾病]