DESMOSOME

作品数：5被引量：13H指数：2
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相关领域：医药卫生更多>>
相关机构：台湾大学更多>>
相关期刊：《World Journal of Gastroenterology》《Chinese Medical Journal》《World Journal of Cardiology》《World Journal of Stem Cells》更多>>
相关基金：国家自然科学基金更多>>
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Disease modeling of desmosome-related cardiomyopathy using induced pluripotent stem cell-derived cardiomyocytes
《World Journal of Stem Cells》2023年第3期71-82,共12页Shuichiro Higo 
Supported by JSPS KAKENHI,No.20K21602,No.21H02915,and No.22K19526;the Japan Agency for Medical Research and Development,No.21bm0804008h0005;the Cell Science Research Foundation;the Grant for Basic Research of the Japanese Circulation Society(2018);SENSHIN Medical Research Foundation.
Cardiomyopathy is a pathological condition characterized by cardiac pump failure due to myocardial dysfunction and the major cause of advanced heart failure requiring heart transplantation.Although optimized medical t...
关键词：CARDIOMYOPATHY Advanced heart failure Induced pluripotent stem cell-derived cardiomyocytes DESMOSOME Genome editing Gene therapy 
Reactivation of PPARαalleviates myocardial lipid accumulation and cardiac dysfunction by improving fatty acidβ-oxidation in Dsg2-deficient arrhythmogenic cardiomyopathy被引量：1
《Acta Pharmaceutica Sinica B》2023年第1期192-203,共12页Yubi Lin Ruonan Liu Yanling Huang Zhe Yang Jianzhong Xian Jingmin Huang Zirui Qiu Xiufang Lin Mengzhen Zhang Hui Chen Huadong Wang Jiana Huang Geyang Xu 
supported by grants from the National Natural Science Foundation of China(82170818,81770794,31401001);the Fundamental Research Funds for the Central Universities(21620423,China);the Science and Technology Project of Zhuhai(20191210E030072,China)。
Arrhythmogenic cardiomyopathy(ACM),a fatal heart disease characterized by fibroadipocytic replacement of cardiac myocytes,accounts for 20%of sudden cardiac death and lacks effective treatment.It is often caused by mut...
关键词：Arrhythmogenic cardiomyopathy DESMOSOME Desmoglein2 Heart failure Lipid accumulation mTOR PPARa FA oxidation 
Desmoplakin and clinical manifestations of desmoplakin cardiomyopathy被引量：3
《Chinese Medical Journal》2021年第15期1771-1779,共9页Zhong-Yu Yuan Li-Ting Cheng Ze-Feng Wang Yong-Quan Wu 
a grant from the Capital’s Funds for Healthlmprovement and Research(No.CRF 2020-2-2062).
Desmoplakin(DSP),encoded by the DSP gene,is the main desmosome component and is abundant in the myocardial tissue.There are three DSP isoforms that assume the role of supporting structural stability through intercellu...
关键词：DESMOPLAKIN DESMOSOME MUTATION Wnt Signaling Pathway CARDIOMYOPATHY 
Alterations in cell adhesion proteins and cardiomyopathy被引量：2
《World Journal of Cardiology》2014年第5期304-313,共10页Jifen Li 
Supported by American Heart Association Scientist Development Grant,No.N2080068;W.W.Smith Charitable Trust Foundation Grant(H1204)
Cell adhesive junction is specialized intercellular struc-ture composed of cell adhesion proteins. They are essential to connect adjacent heart muscle cell and make heart contraction effectively and properly. Clini-ca...
关键词：CARDIOMYOPATHY Adherens junction DESMOSOME INTERCALATED DISC ARRHYTHMIA 
Interleukin-6, desmosome and tight junction protein expression levels in reflux esophagitis-affected mucosa被引量：7
《World Journal of Gastroenterology》2009年第29期3621-3630,共10页Fei-Yue Li Yan Li 
Supported by A grant from the Doctoral Program of China Medical University
AIM： To investigate the correlation between the expression levels of interleukin （IL）-6 and proteins in tight junctions （TJs） in the esophageal mucosa of rats modeling different types of reflux esophagitis （RE）...
关键词：Reflux esophagitis DESMOSOME Tightjunction PROTEINS MUCOSA 
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