Emblica officinalis improves glycemic status and oxidative stress in STZ induced type 2 diabetic model rats  

作　　者：Aneesa Ansari Md.Shahed Zaman Shahriar Md.Mehedi Hassan Shukla Rani Das Begum Rokeya Md.Anwarul Haque Md.Enamul Haque Nirupam Biswas Tama Sarkar 

机构地区：[1]Department of Genetic Engineering and Biolechnology,Jessore Science and Technology University,Jessore,Bangladesh [2]Department of Biotechnology and Genetic Engineering,Islamic University,Kushtia,Bangladesh [3]Department of Biomedical Science,Chonbuk National University Medical School,Jeonju 561-712,South Korea [4]Department of Biochemistry and Molecular Biology,Hajee Mohammad Danesh Science & Technology University,Dinajpur,Bangladesh [5]Department of Biochemistry and Cell Biology,Bangladesh Institute of Research and Rehabilitation in Diabetes,Endocrine and Metabolic Disorders (BIRDEM),Dhaka,Bangladesh [6]Department of Biochemistry and Molecular Biology,University of Dhaka,Dhaka-1000,Bangladesh [7]Department of Nutrition and Food Sciences,University of Huddersfield,Huddersfiled,HD1 3DH,United Kingdom [8]Department of Applied Nutrition and Food Technology,Islamic University,Kushtia,Bangladesh

出　　处：《Asian Pacific Journal of Tropical Medicine》2014年第1期21-25,共5页亚太热带医药杂志（英文版）

基　　金：Shahhag, Dhaka. Bangladesh, for providing technical moral ami financial support for this project

摘　　要：Objective:To evaluate the antidiabetic and antioxidant potential of Emblica officinalis(E.officinalis)fruit on normal and type 2 diabetic rats.Methods:Type 2 diabetes was induced into the male Long-Evans rats.The rats were divided into nine groups including control groups receiving water,type 2 diabetic controls,type 2 diabetic rats treated with glibenclamide(T2GT)and type 2diabetic rats treated with aqueous extract of fruit pulp of E.officinalis.They were fed orally for8 weeks with a single feeding.Blood was collected by cutting the tail tip on 0 and 28 days and by decapitation on 56 day.Packed red blood cells and serum were used for evaluating different biochemical parameters.Results:Four weeks administration of aqueous extract of E.officinalis improved oral glucose tolerance in type 2 rats and after 8 weeks it caused significant(P<0.007)reduction in fasting serum glucose level compared to 0 day.Triglycerides decreased by 14%but there was no significant change in serum ALT,creatinine,cholesterol and insulin level in any group.Furthermore,reduced erythrocyte malondialdehyde level showed no significant change(P<0.07)but reduced glutathione content was found to be increased significantly(P<0.05).Conclusions:The aqueous extract of E.officinalis has a promising antidiabetic and antioxidant properties and may be considered for further clinical studies in drug development.Objective:To evaluate the antidiabetic and antioxidant potential of Emblica officinalis(E.officinalis)fruit on normal and type 2 diabetic rats.Methods:Type 2 diabetes was induced into the male Long-Evans rats.The rats were divided into nine groups including control groups receiving water,type 2 diabetic controls,type 2 diabetic rats treated with glibenclamide(T2GT)and type 2diabetic rats treated with aqueous extract of fruit pulp of E.officinalis.They were fed orally for8 weeks with a single feeding.Blood was collected by cutting the tail tip on 0 and 28 days and by decapitation on 56 day.Packed red blood cells and serum were used for evaluating different biochemical parameters.Results:Four weeks administration of aqueous extract of E.officinalis improved oral glucose tolerance in type 2 rats and after 8 weeks it caused significant(P&lt;0.007)reduction in fasting serum glucose level compared to 0 day.Triglycerides decreased by 14%but there was no significant change in serum ALT,creatinine,cholesterol and insulin level in any group.Furthermore,reduced erythrocyte malondialdehyde level showed no significant change(P&lt;0.07)but reduced glutathione content was found to be increased significantly(P&lt;0.05).Conclusions:The aqueous extract of E.officinalis has a promising antidiabetic and antioxidant properties and may be considered for further clinical studies in drug development.

关 键 词：Antioxidant Emblica OFFICINALIS Non-insulin dependent diabetes MELLITUS TYPE 2 diabetic RATS Reduced GLUTATHIONE 

分 类 号：R285.5[医药卫生—中药学]