Cytokine levels in patients with chikungunya virus infection  

作　　者：Chintana Chirathaworn Yong Poovorawan Somrat Lertmaharit Norra Wuttirattanakowit 

机构地区：[1]Department of Microbiology, Faculty of Medicine, Chulalongkorn University [2]Department of Pediatrics, Faculty of Medicine, Chulalongkorn University [3]Department of Preventive and Social Medicine, Faculty of Medicine, Chulalongkorn University [4]Narathiwatratchanakharin Hospital

出　　处：《Asian Pacific Journal of Tropical Medicine》2013年第8期631-634,共4页亚太热带医药杂志（英文版）

基　　金：supported by the Higher Education Research Promotion and National Research University Project of Thailand, Office of the Higher Education Commission (HR1155A);Thailand Research Fund (DPG5480002);the Commission on Higher Education, Ministry of Education, and the Center of Excellence in Clinical Virology, Chulalongkorn University, Centenary Academic Development Project

摘　　要：Objective: To investigate cytokine profile in patients with chikungunya virus (CHIKV) infection. Methods: Twenty eight pairs of serum samples collected from CHIKV infected patients during the outbreak of chikungunya fever in South Thailand in 2008 were obtained. A multiple cytokine assay for detection of 17 cytokines was performed. Results: In the acute stage of CHIKV infection, the patients had significantly higher levels of interleukin-6, granulocyte colony-stimulating factor, granulocyte-macrophage colony-stimulating factor, monocyte chemotactic protein 1 and tumor necrosis factor alpha than the control ( P<0.001, P=0.023, P=0.015, P <0.001 and P=0.024, respectively). When the disease developed to the recovery stage, the patients had significantly lower levels of interleukin-6, granulocyte-macrophage colony-stimulating factor, monocyte chemotactic protein 1 and macrophage inflammatory protein beta than in the acute stage ( P<0.001). Conclusions: This study provides additional information that these cytokines could play roles in pathogenesis of CHIKV infection and could be used as disease biomarkers or drug targets.Objective: To investigate cytokine profile in patients with chikungunya virus (CHIKV) infection. Methods: Twenty eight pairs of serum samples collected from CHIKV infected patients during the outbreak of chikungunya fever in South Thailand in 2008 were obtained. A multiple cytokine assay for detection of 17 cytokines was performed. Results: In the acute stage of CHIKV infection, the patients had significantly higher levels of interleukin-6, granulocyte colony-stimulating factor, granulocyte-macrophage colony-stimulating factor, monocyte chemotactic protein 1 and tumor necrosis factor alpha than the control ( P&lt;0.001, P=0.023, P=0.015, P &lt;0.001 and P=0.024, respectively). When the disease developed to the recovery stage, the patients had significantly lower levels of interleukin-6, granulocyte-macrophage colony-stimulating factor, monocyte chemotactic protein 1 and macrophage inflammatory protein beta than in the acute stage ( P&lt;0.001). Conclusions: This study provides additional information that these cytokines could play roles in pathogenesis of CHIKV infection and could be used as disease biomarkers or drug targets.

关 键 词：CHIKUNGUNYA virus CYTOKINE INTERLEUKIN-6 Granulocyte-macrophage colonystimulating factor MONOCYTE chemotactic protein 1 

分 类 号：R512.8[医药卫生—内科学]