Influence of Withania somnifera on obsessive compulsive disorder in mice  

作　　者：Bhanu PS Kaurav Manish M Wanjari Amol Chandekar Nagendra Singh Chauhan Neeraj Upmanyu 

机构地区：[1]Department of Pharmacology,R.K.D.F.College of Pharmacy,Bhopal M.P.India [2]Department of Pharmacology,Central Research Institute(ay.) Amkho,Gwalior,M.P.India [3]Department,of Pharmaceutical Sciences.Doctor Hari Singh Gour Vishwavidyalaya Sagar-470003(M.P.) India [4]Department of Pharmaceutical Sciences,Doctor Hari Singh Gour Vishwavidyalaya Sagar-470003(M.P.) India

出　　处：《Asian Pacific Journal of Tropical Medicine》2012年第5期380-384,共5页亚太热带医药杂志（英文版）

摘　　要：Objective:To study the influence of methanolic and aqueous extract of Withania somnifera (W.somnifera) root on the marble-burying behavior of mice a well-accepted model of obsessive compulsive behavior.Methods:Mice were divided in different groups(n=6).Fluoxetine(5,10,15 mg/kg), (10,25,50,100 mg/kg) and melhanolic extract W.somnifera(MEWS)(10,25,50,100 mg/kg) were administered i.p.30 min.prior to the assessment of marble burying behavior and locomotor activity.The control group received vehicle of the extract.Results:Administration of aqueous extracts W.somnifera(AEWS) and MEWS(50 mg/kg) successively decreaesed the marble burying behavior activity without affecting motor activity.This effect of AEWS and MEWS was comparable to standard fluoxetine,ritanserin and parachlorophenylalanine.Conclusions:W.somnifera extract is effective in treating obsessive compulsive disorder.Objective:To study the influence of methanolic and aqueous extract of Withania somnifera (W.somnifera) root on the marble-burying behavior of mice a well-accepted model of obsessive compulsive behavior.Methods:Mice were divided in different groups(n=6).Fluoxetine(5,10,15 mg/kg), (10,25,50,100 mg/kg) and melhanolic extract W.somnifera(MEWS)(10,25,50,100 mg/kg) were administered i.p.30 min.prior to the assessment of marble burying behavior and locomotor activity.The control group received vehicle of the extract.Results:Administration of aqueous extracts W.somnifera(AEWS) and MEWS(50 mg/kg) successively decreaesed the marble burying behavior activity without affecting motor activity.This effect of AEWS and MEWS was comparable to standard fluoxetine,ritanserin and parachlorophenylalanine.Conclusions:W.somnifera extract is effective in treating obsessive compulsive disorder.

关 键 词：WITHANIA somnifera FLUOXETINE RITANSERIN Parachlorophenylalanine OBSESSIVE COMPULSIVE behavior 

分 类 号：R749.7[医药卫生—神经病学与精神病学]