Artemisinin resistance or tolerance in human malaria patients  

作　　者：Jerapan Krungkrai Waranya Imprasittichai Sumintra Otjungreed Sawirasagee Pongsabut Sudaratana R Krungkrai 

机构地区：[1]Department of Biochemistry,Faculty of Medicine,Chulalongkorn University [2]Unit of Biochemistry,Department of Medical Science,Faculty of Science,Rangsit University

出　　处：《Asian Pacific Journal of Tropical Medicine》2010年第9期748-753,共6页亚太热带医药杂志（英文版）

基　　金：supported by the UNDP/ World Bank/WHO Special Programme for Research and Training in Tropical Diseases;the National Science and Technology Development Agency of Thailand(Career Development Award);the Thailand Research Fund(Basic Research);the Office of Higher Education Commission (University Staff Development Consortium),Thailand

摘　　要：Malaria is a major cause of morbidity and mortality in the developing world.This situation is mainly due to emergence of resistance to most antimalarial drugs currently available. Artemisinin-based combination treatments are now first-line drugs for Plasmodium falciparum (P.falciparum) malaria.Artemisinin(qinghaosu) and its derivatives are the most rapid acting and efficacious antimalarial drugs.This review highlights most recent investigations into the emergence of artemisinin resistance in falciparum malaria patients on the Thai-Cambodian border,a historical epicenter for multidrug resistance spread spanning over 50 years.The study presents the first evidence that highlights the parasites reduced susceptibility to artemisinin treatment by prolonged parasite-clearance times,raising considerable concern on resistance development.Although the exact mechanism of action remains unresolved,development of resistance was proposed based from both in vitro experiments and human patients.Lines of evidence suggested that the parasites in the patients are in dormant forms,presumably tolerate to the drug pressure.The World Health Organization has launched for prevention and/or containment of the artemisinin-resistant malaria parasites.Taken together,the emergence of artemisinin resistance to the most potent antidote for falciparum malaria,poses a serious threat to global malaria control and prompts renewed efforts for urgent development of new antimalarial weapons.Malaria is a major cause of morbidity and mortality in the developing world.This situation is mainly due to emergence of resistance to most antimalarial drugs currently available. Artemisinin-based combination treatments are now first-line drugs for Plasmodium falciparum (P.falciparum) malaria.Artemisinin(qinghaosu) and its derivatives are the most rapid acting and efficacious antimalarial drugs.This review highlights most recent investigations into the emergence of artemisinin resistance in falciparum malaria patients on the Thai-Cambodian border,a historical epicenter for multidrug resistance spread spanning over 50 years.The study presents the first evidence that highlights the parasites reduced susceptibility to artemisinin treatment by prolonged parasite-clearance times,raising considerable concern on resistance development.Although the exact mechanism of action remains unresolved,development of resistance was proposed based from both in vitro experiments and human patients.Lines of evidence suggested that the parasites in the patients are in dormant forms,presumably tolerate to the drug pressure.The World Health Organization has launched for prevention and/or containment of the artemisinin-resistant malaria parasites.Taken together,the emergence of artemisinin resistance to the most potent antidote for falciparum malaria,poses a serious threat to global malaria control and prompts renewed efforts for urgent development of new antimalarial weapons.

关 键 词：MALARIA PLASMODIUM FALCIPARUM CHEMOTHERAPY ARTEMISININ Drug RESISTANCE 

分 类 号：R285[医药卫生—中药学]