Effect of malaria components on blood mononuclear cells involved in immune response  

作　　者：chuchard Punsawad 

机构地区：[1]School of Medicine,Walailak University,222 Thasala District,Nakhon Si Thammarat 80161,Thailand

出　　处：《Asian Pacific Journal of Tropical Biomedicine》2013年第9期751-756,共6页亚太热带生物医学杂志（英文版）

基　　金：Supported by the Institute of Research and Development,Walailak University,Nakhon Si Thammarat,Thailand

摘　　要：During malaria infection,elevated levels of pro-inflammatory mediators and nitric;oxide production have been associated with pathogenesis and disease severity.Previous in vitro and in vivo studies have proposed that both Plasmodium falciparum hemozoin and glycosylphosphatidylinositols are able to modulate blood mononuclear cells,contributing to stimulation of signal transduction and downstream regulation of the NF-KB signaling pathway,and subsequently leading to the production of pro-inflammatory cytokines,chemokines,and nitric oxide.The present review summarizes the published in vitro and in vivo studies that have investigated the mechanism of intracellular signal transduction and activation of the NF-KB signaling pathway in blood mononuclear cells after being inducted by Plasmodium falciparum malaria components.Particular attention is paid to hemozoin and glycosylphosphatidylinositols which reflect the important mechanism of signaling pathways involved in immune response.During malaria infection,elevated levels of pro-inflammatory mediators and nitric;oxide production have been associated with pathogenesis and disease severity.Previous in vitro and in vivo studies have proposed that both Plasmodium falciparum hemozoin and glycosylphosphatidylinositols are able to modulate blood mononuclear cells,contributing to stimulation of signal transduction and downstream regulation of the NF-KB signaling pathway,and subsequently leading to the production of pro-inflammatory cytokines,chemokines,and nitric oxide.The present review summarizes the published in vitro and in vivo studies that have investigated the mechanism of intracellular signal transduction and activation of the NF-KB signaling pathway in blood mononuclear cells after being inducted by Plasmodium falciparum malaria components.Particular attention is paid to hemozoin and glycosylphosphatidylinositols which reflect the important mechanism of signaling pathways involved in immune response.

关 键 词：MALARIA COMPONENTS HEMOZOIN Glycosylphosphatidylinositols Nuclear factor KAPPA B BLOOD MONONUCLEAR cells 

分 类 号：R531.3[医药卫生—内科学]