Retinoblastoma: concerning its initiation and treatment  

作　　者：Chang Luo Ying-Ping Deng 

机构地区：[1]Department of Ophthalmology, West China Hospital, Sichuan University

出　　处：《International Journal of Ophthalmology(English edition)》2013年第3期397-401,共5页国际眼科杂志（英文版）

摘　　要：·Retinoblastoma (RB) is the most common intraocular cancer of infancy and childhood. This cancer is initiated by mutation on , the tumor suppressor gene that is responsible for the regulation of both cell cycle and gnome stability in retinal cells. Patients with a constitutional mutation on can be inherited. RB occurs approximately 1 in every 15 000-20 000 live births. The worldwide mortality for this cancer is about 5%-11%. However, this rate rises to about 40%-70% in developing countries due to a delay in diagnosis. A wide variety of options are available for the treatment, but often a combination of therapies is adopted to optimize individualized care. ··Retinoblastoma (RB) is the most common intraocular cancer of infancy and childhood. This cancer is initiated by mutation on , the tumor suppressor gene that is responsible for the regulation of both cell cycle and gnome stability in retinal cells. Patients with a constitutional mutation on can be inherited. RB occurs approximately 1 in every 15 000-20 000 live births. The worldwide mortality for this cancer is about 5%-11%. However, this rate rises to about 40%-70% in developing countries due to a delay in diagnosis. A wide variety of options are available for the treatment, but often a combination of therapies is adopted to optimize individualized care. ·

关 键 词：RETINOBLASTOMA retinoblastomal gene LEUKOCORIA EPIDEMIOLOGY medical management 

分 类 号：R739.7[医药卫生—肿瘤]