DGAVP易化记忆巩固过程与脑内蛋白质合成关系的探讨  

A STUDY OF RELATIONS BETWEEN THE FACILITATED EFFECT OF DGAVP ON MEMORY CONSOLIDATION PROCESSES AND CEREBRAL PROTEIN SYNTHESIS IN MICE

作　　者：林玲[1] 吴馥梅[1] 萧信生[1] 

机构地区：[1]南京大学生物系

出　　处：《心理学报》1986年第4期396-402,共7页Acta Psychologica Sinica

摘　　要：本实验研究了脱甘氨酰胺精氨酸加压素(DGAVP)易化记忆巩固过程的作用,证明DGAVP能够防止蛋白质合成抑制剂茴香霉素(ANI)对记忆的破坏作用,并从突触体水平上探讨了DGAVP的作用与蛋白质合成的关系。 实验结果表明:(1)在复杂迷宫趋食反应中,DGAVP能够增强小鼠对觅食路径的记忆。(2)ANI破坏小鼠的记忆,而预先给予DGAVP则能防止ANI的破坏作用;在一次性被动回避反应中ANI和DGAVP的作用与迷宫实验的结果一致。(3)ANI抑制究触体对蛋白质合成前体亮氨酸的摄取,作用非常显著。DGAVP能够改善ANI的抑制效应,体外和体内的实验结果完全一致。实验结果提示DGAVP的作用机制与蛋白质合成有一定关系。The effects of desglysinamide-arginine-8-vasopressin(DGAVP) onfacilitating memory consolidation processes and alleriating amnesiainduced by the protein synthesis inhibitor anisomycin (ANI) werestudied. The effects of DGAVP on protein synthesis at the level ofhippocampal synaptosomes were also observed. The main results of the experiment are as follows: 1. The mice treated with DGAVP took shorter time to arrive atthe destination than the saline-treated controls 72 hours after complexappetitive maze training. 2. ANI impaired retention as the mice injected with ANI requiredlonger time in the maze test. But the impairment can be prevented byadministering DGAVP in advance, in which case the mice ransignificantly faster to the food than saline ANI-treated animals. Theobservations on passive avoidance response coincided with those onappetitive maze test. 3. ANI reduced the incorporation of [~3H]-leucine into the synapto-somes (P<0.01). DGAVP prevented the inhibitive effect of ANI andkept the memory consolidation processes at normal level. The resultsobtained in vivo and in vitro were completely identical. These resultssuggest that DGAVP's effect on facilitating memory consolidation proc-esses is associated with the regulation of protein synthesis.

关 键 词：DGA 蛋白质合成抑制剂 作用机制 记忆过程 关系 突触体 摄取量 亮氨酸 小鼠 记忆巩固 

分 类 号：B[哲学宗教]