加压素对记忆巩固过程作用的研究 Ⅰ.精氨酸加压素(AVP)对大鼠记忆巩固过程的易化作用及脑内游离氨基酸含量的变化  

THE EFFECT OF VASOPRESSIN ON PROCESSES OF MEMORY CONSOLIDATION ——Ⅰ.The facilitating Effect of AVP on Processes of Memory Consolidation and the Change of Free Amino Acid in Rat Brain

作　　者：萧信生[1] 万瑞谦 杜坤大 

机构地区：[1]南京大学生物系生理教研室

出　　处：《心理学报》1983年第1期111-117,共7页Acta Psychologica Sinica

摘　　要：本文研究了精氨酸加压素易化记忆巩固过程的作用,测定了这一作用过程中脑内15种游离氨基酸含量的变化。 1.第三天建立实验前1小时皮下注射AVP(2μg/只)显著地延缓了大鼠主动逃避条件反应的消退过程。 2.给予AVP的动物在建立期皮层视区和海马两脑区的GABA(γ-氨基丁酸)含量及海马的异亮氨酸含量下降。在保持期两脑区的苏氨酸含量下降,赖氨酸含量上升,海马的谷氨酸含量下降,但两脑区的GABA含量都没有显著变化。 3.电击应激反应的实验结果表明,给予AVP的动物海马的GABA含量及皮层视区苯丙氨酸含量下降。单独注射AVP后1小时,两脑区的天冬氨酸含量下降。AVP注射后48小时,脑内各种氨基酸含量都没有明显变化。The effect that arginine-8-vasopressin(AVP) facilitates memory consolida-tion in rats and the change in contents of the fifteen free amino acids of thebrain are investigated. 1. A single subcutaneous injection of AVP (2μg/rat) 1 hour prior tothe third acquisition session significantly increases resistance to the extinctionof pole jumping avoidance response. 2. Following AVP treatment,the amount of GABA in both visualareas and hippocampi and that of isoleucine in the hippocampi are decreasedafter the third acquisition session.After the second extinction the differentchange was observed.The amount of threonine in both visual areas andhippocampi and that of glutamate in the hippocampi are lowered,whereas theamount of lysine in the two regions are elevated in comparison with control,but no change in GABA amount occurs. 3. The experimental result of electric stress response shows that theamount of GABA in the hippocampi and that of phenylalanine in the visualareas are lowered as compared to control.The lowered amount of asparticacid in the two regions is observed 1 hour after the administration of AVP,but no significant difference in contents of any free amino acids is presented48 hours after the administration of AVP.

关 键 词：记忆巩固 游离氨基酸含量 精氨酸加压素 海马 脑内 含量变化 动物 GABA 实验结果 脑区 

分 类 号：B[哲学宗教]