MTHFR基因C677T纯合突变与偏头痛发病风险的meta分析  

Association between homozygous C677T mutation in MTHFR gene and migraine:a meta-analysis

作　　者：左彦方[1] 李明[1] 郭毅[2] 高展[1] 

机构地区：[1]深圳市龙岗中心医院神经内科,广东深圳518116 [2]暨南大学第二临床医学院神经内科,广东深圳518020

出　　处：《广州医学院学报》2014年第2期47-50,共4页Academic Journal of Guangzhou Medical College

基　　金：深圳龙岗区科技发展基金(YS2013084)

摘　　要：目的:探讨MTHFR基因C677T纯合突变与偏头痛的相关性。方法:应用RevMan 5.0软件对20000年1月到2013年12月之间发表的有关MTHFR基因C677T多态性与偏头痛相关性的22项相关研究的文献进行了荟萃分析,共纳入8622例偏头痛患者,28376例对照。结果:随机效应模型分析结果显示,TT基因型能增加先兆型偏头痛发病风险,OR 1.45[95%CI,1.10~1.92];但不能增加无先兆偏头痛发病风险,OR 1.01[95%CI,0.91~1.13]。结论:MTHFR基因C677T纯合突变与先兆型偏头痛相关,与无先兆偏头痛无明确相关。TT基因型能增加先兆型偏头痛发病风险。Objective:To investigate the association between the homozygous C677 T mutation in MTHFR gene and migraine.Methods:We performed a meta-analysis of 22 studies comprising 8622 cases and 28376 control subjects investigating the MTHFR C677 T polymorphisms by using the RevMan version 5.0 software.Results:An overall random-effect odds ratio of 1.45(95%confidence interval,1.10 to 1.92) was found for TT genotype in migraine with aura,but not in migraine without aura(odds ratio,1.01,95%confidence interval,0.91 to 1.13).Conclusion:The homozygous C677 T mutation in MTHFR gene is associated with migraine with aura,but not in migraine without aura.There is an increased risk of migraine with aura associated with the TT genotype.

关 键 词：亚甲基四氢叶酸还原酶 C677T 偏头痛 META分析 

分 类 号：R747.2[医药卫生—神经病学与精神病学]