supported by the National Nature Science Foundation of China(82330021,82061160372,82270771);the National Key Research and Development Program(2020YFC2004405);the Shenzhen Key Laboratory of Precision Prevention and Control of Major Chronic Diseases and Metabolic Research(ZDSYS20220606100801004);the Central Military Commission Key Project of Basic Research for Application(BWJ21J003);the Regional Joint Funding Key Project of Guangdong Basic Research and Basic Research for Application(2021B1515120083);the Key Project of Sustainable Development Science and Technology of Shenzhen Science and Technology Innovation Committee(KCXFZ20211020163801002);Shenzhen Science and Technology Program(ZDSYS20220606100801004,SGDX20230116092459009);Shenzhen Medical Research Fund(B2302020);Shenzhen Key Medical Discipline Construction Fund(SZXK002);the Sun Yat-sen University-Shenzhen TAILORED Medical Ltd.Postgraduate joint training base,the Futian District Public Health Scientific Research Project of Shenzhen(FTWS2022001);Department of Cardiology,Joint Laboratory of Guangdong-Hong Kong-Macao Universities for Nutritional Metabolism and Precise Prevention and Control of Major Chronic Diseases,the Eighth Affiliated Hospital of Sun Yat-sen University,Shenzhen,the Chinese Association of Integrative Medicine-Shanghai Hutchison Pharmaceuticals Fund(HMPE202202);China Heart House-Chinese Cardiovascular Association HX fund(2022-CCA-HX-090);the Shenzhen Key Medical Discipline Construction Fund(SZXK002)to H.H;Shenzhen Medical Research Fund(A2302013)to Zhengzhipeng Zhang;The fifth“333”high-level talent training project of Jiangsu Province(BRA2019247);Medical Research Project of Jiangsu Provincial Health Commission in 2020(ZDA2020018).
Previous studies have shown that low platelet count combined with high plasma total homocysteine(tHcy)increased stroke risk and can be lowered by 73% with folic acid.However,the combined role of other platelet activat...