Endogenous enkephalin does not contribute to the cerebral anti-hyperalgesic action of gabapentin  

作　　者：CHEN ShaoHui ZHAO Jing HUANG YuGuang LUO AiLun ZUO PingPing YANG Nan HAO WenYu 

机构地区：[1]Department of Anesthesia,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing 100730,China [2]Department of Pharmacology,Institute of Basic Medical Sciences,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing 100005,China

出　　处：《Science China(Life Sciences)》2010年第12期1428-1432,共5页中国科学(生命科学英文版)

摘　　要：The aim of this study was to investigate the role of endogenous enkephalin in the cerebral antihyperalgesic action of gabapentin.Neuropathic pain models and antihyperalgesic effect of gabapentin were confirmed by the presentation and changes of mechanical allodynia and thermal hyperalgesia of operated mouse hind paws.The results suggested that endogenous enkephalin may not be involved in the antihyperalgesic effect of gabapentin.The aim of this study was to investigate the role of endogenous enkephalin in the cerebral antihyperalgesic action of gabapentin.Neuropathic pain models and antihyperalgesic effect of gabapentin were confirmed by the presentation and changes of mechanical allodynia and thermal hyperalgesia of operated mouse hind paws.The results suggested that endogenous enkephalin may not be involved in the antihyperalgesic effect of gabapentin.

关 键 词：neuropathic pain GABAPENTIN ENKEPHALIN cerebral cortex 

分 类 号：Q42[生物学—神经生物学]