[Objectives]To discuss the curative effect of the external application of self-prepared Chinese prescription decoction combined with gabapentin and cotton moxibustion on postherpetic neuralgia(PHN)and analyze its mech...
Objective:To assess the efficacy of gabapentin in the treatment of low back pain patients.Methods:This prospective observational study was conducted over 6 months to assess the efficacy of gabapentin in patients suffe...
Pain is defined as an unpleasant sensory and emotional experience, associated with actual or potential tissue damage. According to its neurobiological mechanism, pain is classified into nociceptive, inflammatory, dysf...
Gabapentin(Neurontin)is an anti-epileptic drug that has had wide off-label prescription use since market release due to presumed negligible abuse potential.However,trends in drug misuse have demonstrated that gabapent...
Background & Aims: The multimodal analgesia provides superior pain relief and reduces opioid consumption and its side effects. Gabapentin has been used successfully in multi-modal analgesia in different doses. ...
Supported by Sichuan Science and Technology Program,No.2018SZ0386。
Neuropathic pain(NPP)is a kind of pain caused by disease or damage impacting the somatosensory system.Ion channel drugs are the main treatment for NPP;however,their irregular usage leads to unsatisfactory pain relief....
supported by the National Institute on Alcohol Abuse and Alcoholism(NIAAA)Neurobiology of Adolescent Drinking In Adulthood(NADIA)Grant#2U01AA019925(to HSS);the National Institute on Alcohol Abuse and Alcoholism(NIAAA)R00AA022651(to TAW);the National Institute on Drug Abuse(NIDA)R01DA041455(to KJR)
Adolescent alcohol abuse is a substantive public health problem that has been the subject of intensive study in recent years.Despite reports of a wide range of effects of adolescent intermittent ethanol(AIE)exposure o...
Gabapentin, and pregabalin had been used in analgesic field some studies. This double blind randomized clinical trial was conducted to evaluate the pre-emptive use of gabapentin 900 mg and pregabalin 300 mg in reducin...
supported by the National Natural Science Fundation of China(No.51776130);the Natural Science Foundation of Shanghai(No.12ZR1420400);Innovation Foundation from the Education Commission of Shanghai City(No.14YZ092)
Gabapentin undergoes intramolecular cyclization by alkylamine nucleophilic attacking on carboxylate carbonyl. And the above self-dehydration condensation can produce gabapentin lactam which has some toxic effects. The...