BACKGROUND Chronic neuropathic pain and depression are common and debilitating conditions in cancer patients,significantly impacting their quality of life.Pregabalin,an anticonvulsant medication,is used for neuropathi...
BACKGROUND Pregabalin is widely used to treat neuropathic pain associated with postherpetic neuralgia.To our knowledge,this is the first report on simultaneously occurring dose-related adverse drug reactions(ADRs)of b...
Pain is defined as an unpleasant sensory and emotional experience, associated with actual or potential tissue damage. According to its neurobiological mechanism, pain is classified into nociceptive, inflammatory, dysf...
Supported by Sichuan Science and Technology Program,No.2018SZ0386。
Neuropathic pain(NPP)is a kind of pain caused by disease or damage impacting the somatosensory system.Ion channel drugs are the main treatment for NPP;however,their irregular usage leads to unsatisfactory pain relief....
Gabapentin, and pregabalin had been used in analgesic field some studies. This double blind randomized clinical trial was conducted to evaluate the pre-emptive use of gabapentin 900 mg and pregabalin 300 mg in reducin...
Background: Tracheal intubation is a noxious stimulus that tends to provoke a marked sympathetic response which is potentially deleterious in some patients. Various methods have been used to minimize and attenuate the...
Pregabalin,(S)-3-amino methyl hexanoic acid,is a structural analogue ofγ-amino butyric acid(GABA)which has been widely used to treat partial seizures and neuropathic pain[1].It is soluble in aqueous solution and spar...
Acknowledgements This study was supported in part by grants-in-aid for scientific research from the the National Basic Research Program of China (2011CB711000 and 2015CB856401), the National Natural Science Foundation of China (31171010, 31121061, 31271164, 31471064, 81420108015, J1210041, and 81301135), Shanghai Committee of Science and Technology (13140903100, 14JC1400900, 13dz2260700 and 13ZR1403200), a key laboratory program of the Education Commission of Shanghai Municipality (ZDSYS14005), and the Shanghai Leading Academic Discipline Project (B119).
Aim: Gelsemine, an alkaloid from the Chinese herb Gelsemium elegans (Gardn & Champ) Benth, is effective in mitigating chronic pain in rats. In the present study we investigated whether the alkaloid improved sleep ...
Objective: To study the effect of addition of Metanx?on burning parasthesias in patients with symptomatic diabetic neuropathy who had obtained only partial symptom resolution with pregabalin. Research design and metho...